Skip to main content
SpringerLink
Log in

Non-invasive assessment of coronary flow velocity reserve: A new method using transthoracic Doppler echocardiography

  • Published:
Current Medical Science Aims and scope Submit manuscript

Summary

Transthoracic Doppler echocardiography (TTDE) allows noninvasive flow measurement in the distal left anterior descending artery (LAD). The feasibility of detecting coronary flow by contrast-enhanced TTDE with second harmonic technique was assessed, the coronary flow velocity reserve (CFVR) was evaluated in comparison to intracoronary Doppler flow (ICD) analysis and the CFVR after PTCA in LAD was investigated. In 77 (96%) of 80 patients, CFVR was successfully determined with intravenous adenosine infusion. Doppler signal quality was evaluated in the first 46 patients by use of intravenous Levovist infusion and second harmonic technique. The Doppler flow was not visible in 1 patient only. CFVR determined from TTDE (2.77±0.65) was correlated closely with those from ICD (2.88±0.78) measurements (y=0.73x+0.67,r=0.87,P<0.001). In conclusion, TTDE is a feasible method and provides reliable data on CFVR which can be used for followup after PTCA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kern M J, Deligonul U, Tatineni Set al. Intravenous adenosine: continuous infusion and low dose bolus administration for determination of coronary vasodilator reserve in patients with and without coronary artery disease. J Am Coll Cardiol, 1991, 18: 718

    Article  CAS  PubMed  Google Scholar 

  2. Baumgart D, Haude M, Goerge Get al. Improved assessment of coronary stenosis severity using the relative flow velocity reserve. Circulation, 1998, 98: 40

    Article  CAS  PubMed  Google Scholar 

  3. Wieneke H, Haude M, Ge Jet al. Corrected coronary flow velocity reserve: a new concept for assessing coronary perfusion. J Am Coll Cardiol, 2000, 35: 1713

    Article  CAS  PubMed  Google Scholar 

  4. Erbel R, Ge J, Bockisch Aet al. Value of intracoronary ultrasound and Doppler in the differentiation of angiographically normal coronary arteries: a prospective study in patients with angina pectoris. Eur Heart J, 1996, 17: 880

    Article  CAS  PubMed  Google Scholar 

  5. Erbel R. Transesophageal echocardiography: new window to coronary arteries and coronary blood flow. Circulation, 1991, 83: 339

    Article  CAS  PubMed  Google Scholar 

  6. Caiati C, Montaldo C, Zedda Net al. New noninvasive method for coronary flow reserve assessment. Contrast-enhanced transthoracic second harmonic echo Doppler. Circulation, 1999, 99: 771

    Article  CAS  PubMed  Google Scholar 

  7. Hozumi T, Yoshida K, Akasaka Tet al. Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography. Comparison with invasive technique. J Am Coll Cardiol, 1998, 32: 1251

    Article  CAS  PubMed  Google Scholar 

  8. Iliceto A, Caiati C, Aragona Pet al. Improved Doppler signal intensity in coronary arteries after intravenous peripheral injection of a lung-crossing contrast agent (SHU 508A). J Am Coll Cardiol, 1994, 23: 184

    Article  CAS  PubMed  Google Scholar 

  9. Di Mario C, Meneveau N, Gil Ret al. Maximal blood flow velocity in severe coronary stenosis measurement with a Doppler guide wire: limitations for the application of the continuity equation in the assessment of stenosis severity. Am J Cardiol, 1993, 71: 54D

    Article  PubMed  Google Scholar 

  10. Caiati C, Zedda N, Montaldo Cet al. Contrast-enhanced transthoracic second harmonic echo Doppler with adenosine. A noninvasive, rapid and effective method for coronary flow reserve assessment. J Am Coll Cardiol, 1999, 34: 122

    Article  CAS  PubMed  Google Scholar 

  11. Bartel T, Müller S, Baumgart Det al. Improved high-frequency transthoracic flow velocity measurement in the left anterior descending coronary artery after intravenous peripheral injection of Levovist. J Am Soc Echocardiogr, 1999, 12: 252

    Article  CAS  PubMed  Google Scholar 

  12. Doucette J W, Corl P D, Payne H Met al. Validation of a Doppler guide wire for intravascular measurements of coronary artery flow velocity. Circulation, 1992, 85: 1899

    Article  CAS  PubMed  Google Scholar 

  13. Wilson R F, Wyche K, Christensen B Vet al. Effects of adenosine on human coronary arterial circulation. Circulation, 1990, 82: 1595

    Article  CAS  PubMed  Google Scholar 

  14. Rossen J D, Quillen J E, Lopez A Get al. Comparison of coronary vasodilation with intravenous dipyridamole and adenosine. J Am Coll Cardiol, 1991, 18: 485

    Article  CAS  PubMed  Google Scholar 

  15. Labovitz A J, Ofili E O, Kern M J. Evaluation of coronary flow by intracoronary Doppler flow wire. In Dagianti A, Feigenbaum H, eds. Echocardiography. Shannon, Ireland: Elsevier Science Ireland, 1993, 27–33

    Google Scholar 

  16. Hasdai D, Holmes D R, Higano S Tet al. Effect of basal epicardial tone on endothelium-independent coronary flow reserve measurement. Cathet Cadiovasc Diagn, 1998, 44: 392

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Cardiovascular Disease, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan

    Yang Ya & Wang Xinfang

  2. Department of Cardiology, University Essen, Germany

    Thomas Bartel, Holger Eggebrecht, Loredana Latina, Clemems von Birgelen, Guido Caspari & Raimund Erbel

Authors
  1. Yang Ya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thomas Bartel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Holger Eggebrecht
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Loredana Latina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Clemems von Birgelen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Guido Caspari
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Wang Xinfang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Raimund Erbel
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

YANG Ya, female, born in 1963, Associate Professor

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ya, Y., Bartel, T., Eggebrecht, H. et al. Non-invasive assessment of coronary flow velocity reserve: A new method using transthoracic Doppler echocardiography. Current Medical Science 22, 158–163 (2002). https://doi.org/10.1007/BF02857683

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02857683

Key words

Search

Navigation