Summary
To investigate the changes in neurological symptoms and signs, as well as serum copper, serum ceruloplasmin after hepatic transplantation in patients with Wilson's disease, neurological symptoms and signs, serum copper, serum ceruloplasmin before and after hepatic transplantation in 18 patients with Wilson's disease were observed, and those changes were followed up in 20 non-operative controls treated with penicillamine. Our results showed that the neurological symptoms and signs, serum copper and serum ceruloplasmin were improved in the operative group but deteriorated in the non-operative control group. Our study showed that hepatic transplantation is better than penicillamine in the treatment of Wilson's disease.
Similar content being viewed by others
References
Parrille P, Sanchez B F, Figueras Jet al. Analysis of the complications of piggyback technique in 1112 liver transplant. Transplantation, 1999, 67: 1214
Groth C G. Transplantation today. Vol. 2. New York: Grane Stratton, 1973. 829–833
Stracciari A, Tempestini A, Borghi Aet al. Effect of liver transplantation on neurological manifestation in Wilson disease. Arch Neurol, 2000, 57: 384
Asonuma K, Inomata Y, Kaschara Met al. Living related liver transplantation from heterozygote genetic carriers to children with Wilsons disease. Pediatr Transplant, 1999, 3: 201
Khanna A, Tania A, Eghtesad Bet al. Liver transplantation for metabolic liver disease. Surg Clin North Am, 1999, 79: 153
Schumacher G, Platz K P, Mueller A Ret al. Liver transplantation treatment of choice for hepatic and neurological manifestation of WD. Clin Transplant, 1997, 11: 217
Chen C L, Chen Y S, Chang Y Cet al. Paediatric liver transplantation: a 10 year experience in Taiwan. J Gastroenterol Hepatol, 1996, 11: 81
Schilshy M I, Scheinberg I H, Stemlieb Iet al. Liver transplantation for Wilson's disease: indications and outcome. Hepatology, 1994, 19: 583
Eghtesad B, Nezekatgoo N, Ceraci L Cet al. Liver transplantation for Wilson's disease. Liver Transplant Surg, 1999, 5: 467474
Author information
Authors and Affiliations
Additional information
Tang Ronghua, female, born in 1951, Professor
Rights and permissions
About this article
Cite this article
Ronghua, T., Zheng, X. & Qifa, Y. Wilson's disease and hepatic transplantation. Current Medical Science 22, 142–143 (2002). https://doi.org/10.1007/BF02857678
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02857678