Skip to main content
SpringerLink
Log in

Low and maternal-specific expression of p57KIP2 in hydatidiform mole and its clinical implication

  • Published:
Current Medical Science Aims and scope Submit manuscript

Summary

In situ hybridization was applied to locate and detect the expression of p57KIP2 in hydatidiform mole (5 cases of partial hydatidiform mole and 18 cases of complete hydatidiform mole) and normal villi (23 cases). The positive signals of p57KIP2 expression were analyzed by HPIAS-1000 Image-Analysis System. p57KIP2 was highly expresed in normal villi but showed distinct low expression in hydatidiform mole (P<0.01). Furthermore, the locus of low expression of p57KIP2 accorded with the place where lesion of trophoblast occurred. Detection of p57KIP2 made it possible to study the genetics of hydatidiform mole at the transcriptional level. Low expression of p57KIP2 could be a molecular marker in hydatidiform mole and a target for therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hartmann W, Waha A, Koch Aet al. p57(KIP2) is not mutated in hepatoblastoma but shows increased transcriptional activity in a comparative analysis of the three imprinted genes p57 (KIP2), IGF2, and H19. Am J Pathol, 2000, 157(4): 1393

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Berek J S. Novak's Gynecology. 2th eds. Baltimore: Williams & Wilkins, 1996. 487

    Google Scholar 

  3. Hatada I, Inazawa J, Abe Tet al. Genomic imprinting of human p57KIP2 and its reduced expression in Wilm's tumors. Hum Mol Genet, 1996, 5(6): 783

    Article  CAS  PubMed  Google Scholar 

  4. Kondo M, Matsuoka S, Uchida Ket al. Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5. Oncogene, 1996, 21, 12(6): 1365

    Google Scholar 

  5. Overall M L, Spencer J, Bakker Met al. p57K1P2 is expressed in Wilms' tumor with LOH of 11p15.5. Genes Chromosomes Cancer, 1996, 17(1): 56

    Article  CAS  PubMed  Google Scholar 

  6. Hu R J, Lee M P, Johnson L Aet al. A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues. Hum Mol Genet, 1996, 5(11): 1743

    Article  CAS  PubMed  Google Scholar 

  7. Goshen R, Ben-Rafael Z, Gonik Bet al. The role of genomic imprinting in implantation. Fertil Steril, 1994, 62 (5): 903

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan

    Xiong Yali & Li Hongfa

  2. Department of Ophthalmology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan

    Cao Yang

Authors
  1. Xiong Yali
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cao Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Li Hongfa
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

XIONG Yali, female, born in 1975, M. D., Ph. D.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yali, X., Yang, C. & Hongfa, L. Low and maternal-specific expression of p57KIP2 in hydatidiform mole and its clinical implication. Current Medical Science 22, 121–122 (2002). https://doi.org/10.1007/BF02857671

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02857671

Key words

Search

Navigation