Immunological investigation on hepatitis B virus infection

Summary

A series of immunological studies has been carried out on various types of viral hepatitis B. The positive cell-mediated immunity to HBsAg and LSP and positive HBsAg immune complex accompanied with a reduction in ER positive lymphocytes and abnormal ADCC were observed in chronic active hepatitis, fulminant hepatitis and subacute liver necrosis. The patients studied also showed reduced suppressor cell activity, positive E rosette inhibitory factor and serum inhibitory factor of interferon induction. Temporary positive findings of these immune responses were detected in convalescent patients of acute hepatitis. On the contrary, asymptomatic carriers showed minimal or negative specific cell-mediated immunity and normal suppressor cell activity. Therefore, a classification of immune response in viral hepatitis B has been suggested.