Summary
The thyroid stimulating effect of tissue extracts was studied in rats. The serum levels of T4, T3 and cAMP content of thyroid increased significantly at 2–4th hour and then returned to the initial values at 6th hour after injection of spleen extract. After injection of placenta extract, the same levels increased markedly as well. Their stimulating effects on the thyroid system were probably independent of the response of the adrenal system. Administration of morphine prior to injection of tissue extracts blocked their stimulating effects on serum levels of T4, T3 and the cAMP content of thyroid.
The above results demonstrate that tissue extracts of spleen and placenta are capable of stimulating hypothalamo-pituitary-thyroid axis possibly via hypothalamus.
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Ping, R., Cheng-ren, A., Jing-mai, L. et al. The stimulating effect of tissue extracts on hypothalamo-pituitary-thyroid axis in rats. Acta Academiae Medicinae Wuhan 4, 90–94 (1984). https://doi.org/10.1007/BF02857025
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DOI: https://doi.org/10.1007/BF02857025