Summary
Effects of dauricine (Dau) on the physiologic properties of myocardium were studied in cat papillary muscles. Dau (32 μM) decreased the force of contraction to 72 ±3 % (P<0.01) and depressed markedly the excitability as well as epinephrine-induced automaticity, even in lower concentration (5 μM). It also prolonged the functional refractory period from 315±13 ms to 362±18 ms (P< 0.05). The results obtained indicate that Dau possesses calcium antagonistic effect as well as an inhibitory action on Na+ current in cat papillary muscles.
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References
1982; 11(3): 75–8.
1984.
1982; 3(3): 178–82.
1982; 2(3): 163–6.
1982; 3(2): 97–101.
1966; 29: 43–8.
Dresel PE, Duncan DG. Induction of automaticity in cat papillary muscles by sympathomimetic amines. J Pharmacol Exp Ther 1961; 133:70–5.
Govier WC. The mechanism of the atrial refractory period change produced by ouabain. J Pharmacol Exp Ther 1965; 148:100–5.
Zbinden G, Gross F. Pharmacological Methods in Toxicology. 1st ed, p 73, Oxford: Pergamon Press, 1979: 73.
Dhalla NS, et al. Calcium movements in relations to heart function. Basic Res Cardiol 1982; 77(2): 117–39.
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Gui-rong, L., Da-chao, F., Chong-jia, H. et al. Effects of dauricine on the physiologic properties of myocardium. Acta Academiae Medicinae Wuhan 4, 82–84 (1984). https://doi.org/10.1007/BF02857023
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DOI: https://doi.org/10.1007/BF02857023