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An experimental pathological study of acute lei gong teng (Tripterygium wilfordii Hook) intoxication in rats

Experimentelle pathologische Untersuchung der akuten Vergiftung mit Tripterygium wilfordii Hook bei Ratten

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Summary

Acute poisoning was induced in rats by single and repeated exposures to the decoction of the root bark of Lei Gong Teng. Pathologic changes in the vital organs were studied by light and electron microscopy, and histochemically. The relatively specific and consistent pathologic changes following poisoning were observed in the lymphoid organs. Varying degrees of degeneration and necrosis in the parenchymatous cells existed in the heart, liver and kidney. The mechanism of toxicological pathologic changes and the relation between clinic and pathology were approached, and we postulate that the decoction possesses cytotoxic action which is analogous to that of immunosuppressive agent.

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Authors and Affiliations

  1. Department of Forensic Medicine, Wuhan Medical College, Wuhan

    Zhang Yi-gu & Huang Guang-zhao

  2. Laboratory of Electron Microscopy, Wuhan Medical College, Wuhan

    Wang Hui-jun & Wu Zhong-bi

  3. Hubei Province Academy of Combined Traditional Chinese and Western Medicine, Wuhan

    Xing Su-lan

Authors
  1. Zhang Yi-gu
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  2. Huang Guang-zhao
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  3. Wang Hui-jun
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  4. Wu Zhong-bi
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  5. Xing Su-lan
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Yi-gu, Z., Guang-zhao, H., Hui-jun, W. et al. An experimental pathological study of acute lei gong teng (Tripterygium wilfordii Hook) intoxication in rats. Acta Academiae Medicinae Wuhan 4, 75–81 (1984). https://doi.org/10.1007/BF02857022

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  • DOI: https://doi.org/10.1007/BF02857022

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