Summary
The isolated rat uterus contraction induced by oxytocin and Ca+ + after high-K depolarization were markedly inhibited by tetrandrine (Tet). The depression was immediately reversed by addition of Ca++ to the bath fluid. Tet and verapamil (Ver), which shifted the cumulative dose-response curves to the right and depressed the maximal responses to CaCl2 acted as non-competitive antagonists. The oxytocin-induced Ca++-dependent contractions were depressed by 4.8 and 30 μM Tet. Tet 30 μM also inhibited the Ca++ o-dependent component of the contraction.
The effect of Ver on isolated rat uterus was stronger than that of Tet. But up to 0.05 μM, it showed no effect on Ca+ +-dependent oxytocin contraction.
These results indicate that Tet is an effective Ca+ +-antagonist very similar to Ver on isolated rat uteri.
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Da-chao, F., Wei-xing, Y., Jiao-ling, Z. et al. Studies on the calcium antagonistic action of tetrandrine: VI. Effects of tetrandrine on contractility of isolated rat uterus. Acta Academiae Medicinae Wuhan 4, 69–74 (1984). https://doi.org/10.1007/BF02857021
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DOI: https://doi.org/10.1007/BF02857021