Summary
By86RbCl-extraction method, the effects of tetrandrine (Tet), verapamil (Ver) and propranolol (Pro) on myocardial blood flow of mice were studied. Both I.P. Tet 100 mg/kg and Ver 5 mg/kg increased the blood flow, whereas I.P. Pro 30 mg/kg did not. Pro counteracted significantly the increase of myocardial blood flow by isoproterenol, while Tet and Ver failed. On the other hand, Tet and Ver markedly antagonized the increase of myocardial blood flow by CaCl2, but Pro did not.
The results indicate that unlike the β-receptor blocking agent Pro, Tet may be a calcium antagonist similar to Ver.
Similar content being viewed by others
References
Fang DC, et al. Effects of tetrandrine on isoprenaline and calcium-mediated positive chronotropic action in isolated. rabbit atria. Acta Pharmacol Sinica 1982; 3(4):233–6.
Jin MW, et al. Influence of tetrandrine on positive inotropic action of isoproterenol and CaCl2 and on excitation-contraction coupling in isolated cat papillary muscles. Acta Pharmacol Sinica 1982; 3(2):97–101.
1975; 55(8): 559–61.
Krasnow N, et al. Isoproterenol and cardiovascular performance. Am J Med 1964; 37(4):514–25.
Berne RM, Bufio R. Coronary Circulation. In: Berne RM, et al eds. Handbook of Physiology, Section 2, vol 1. Baltimore: Williams Wilkins, 1979:923–4.
Pitt B, et al. Coronary hemodynamic effects of calcium in the unanesthetized dog. Am J Physiol 1969:216 (6): 1456 -9.
Luebs ED, et al. Effect of nitroglycerine. intensain, isoptin and papaverine on coronary blood flow in man measured by the coincidence counting technic and rubidium86. Am J Cardiol 1966; 17 (4): 535–41.
McKenna DH, et al. Effect of propranolol on systemic and coronary hemodynamics at rest and during simulated exercise. Circ Res 1966: 19 (3): 520–7.
Fleckenstein A. Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. Ann Rev Pharmacol Toxicol 1977; 17:149–66.
Fang DC, et al. Studies on the calcium antagonistic action of tetrandrine; I. Effects of tetrandrine on the isolated guinea pig atrium. Acta Acad Med Wuhan 1981; 46–50.
Yao WX, et al. Effects of tetrandrine, verapamil and propranolol on contractility and cAMP level of isolated rabbit left atria. Acta Pharmacol Sinica 1983; 4(1):29–32.
Fang DC, et al. Effects of tetrandrine on cat papillary muscle. Acta Pharmacol Sinica 1981; 2(3): 163–6.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Da-chao, F., Ju-fang, J., Guo-jin, X. et al. Studies on the calcium antagonistic action of tetrandrine: VI. Comparison of effects of tetrandrine, verapamil and propranolol on myocardial blood flow. Acta Academiae Medicinae Wuhan 4, 65–68 (1984). https://doi.org/10.1007/BF02857020
Issue Date:
DOI: https://doi.org/10.1007/BF02857020