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Preparation and evaluation of ethylcellulose microcapsules of indomethacin

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Abstract

Indomethacin was microencapsulated with ethylcellulose using a modified spherical agglomeration process, aiming at a sustained release preparation without side effects on the stomach. The surface morphology of the microcapsules was examined using scanning electron microscopy. The microcapsules were porous and spherical, and their porosity increased with increasing the viscosity of ethylcellulose.In vitro dissolution process followed Higuchi’s diffusion model for first 3 hr. Release rate of the drug from microcapsules decreased as the viscosity of ethylcellulose or the weight ratio of indomethacin to ethylcellulose was decreased. The release rate also decreased with increasing the microcapsule size. The microcapsules induced less gastric ulcer in rats than raw drug.

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Authors and Affiliations

  1. College of Pharmacy, Seoul National University, 151, Seoul, Korea

    Haeng-Ja Lee, Min-Hwa Lee & Chang-Koo Shim

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  1. Haeng-Ja Lee
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  2. Min-Hwa Lee
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Additional information

A part of this work is taken from a dissertation submitted by H.J. Lee to the Graduate School, College of Pharmacy, Seoul National University, Seoul, Korea, in partial fulfillment of the requirements for the degree of Master of Science.

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Lee, HJ., Lee, MH. & Shim, CK. Preparation and evaluation of ethylcellulose microcapsules of indomethacin. Arch. Pharm. Res. 7, 33–40 (1984). https://doi.org/10.1007/BF02856919

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  • DOI: https://doi.org/10.1007/BF02856919

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