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Effects of lignans on hepatic drug-metabolizing enzymes

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Abstract

The effects of lignans, related to macelignan, on hepatic microsomal drug-metabolizing enzyme (DME) activity were evaluated to elucidate the structure-activity relationship in mice and rats. The compounds carrying the methylenedioxyphenyl nucleus were found to be the most potent among compounds tested; which not only produced a marked inhibition of DME with a single dose but a significant induction with repeated treatments. Lack of the methylenedioxy group caused marked decrease in the activity, implying that a methylenedioxy group is essential and of major importance eliciting DME modifying activity.

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Authors and Affiliations

  1. Natural Products Research Institute, Seoul National University, 110-460, Seoul

    Kuk Hyun Shin & Won Sick Woo

  2. Department of Home Economics, Korea University, 136-072, Seoul, Korea

    Jung Yun Lee & Yong Bong Han

Authors
  1. Kuk Hyun Shin
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  2. Won Sick Woo
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  3. Jung Yun Lee
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  4. Yong Bong Han
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Additional information

Part 15 in the series “Studies on crude drugs action on drug-metabolizing enzymes” For part 14, see ref 1.

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Shin, K.H., Woo, W.S., Lee, J.Y. et al. Effects of lignans on hepatic drug-metabolizing enzymes. Arch. Pharm. Res. 13, 265–268 (1990). https://doi.org/10.1007/BF02856533

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  • DOI: https://doi.org/10.1007/BF02856533

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