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Interaction of flavins and some alcohols on the molecular level

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Abstract

The effect of some alcohols on the riboflavin derivatives in non-polar solvent was studied by various spectroscopic method in order to support the viewpoint that alcohol may directly interact with the isoalloxazine moiety of FAD, the coenzyme of D-amino-acid oxidase. The most possible association complex between alcohol and riboflavin is the 1∶1 complex through the 2-C carbonyl function of the isoalloxazine ring and the hydroxyl proton of alcohol. It is appeared that methanol has a larger association constant than any other alcohols, and the association constant decreases with the carbon number increases and being bulkier in the alkyl group of alcohols.

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Authors and Affiliations

  1. College of Pharmacy, Seoul National University, 151, Seoul, Korea

    Byung Sul Yu, Hyun Ho Chung, Sang Jong Lee, Yang Bae Kim & Chong-Kook Kim

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  1. Byung Sul Yu
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  2. Hyun Ho Chung
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  3. Sang Jong Lee
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  4. Yang Bae Kim
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Yu, B.S., Chung, H.H., Lee, S.J. et al. Interaction of flavins and some alcohols on the molecular level. Arch. Pharm. Res. 4, 43–51 (1981). https://doi.org/10.1007/BF02856440

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  • DOI: https://doi.org/10.1007/BF02856440

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