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The transformation of ginsenosides by acid catalysis in gastric pH

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Abstract

1. The ginsenosides of Korean ginseng decomposed profoundly to produce artifact products of prosapogenin A1, A2 and A3 from ginsenoside Rg1, prosapogenin C1, C2 and C3 from ginsenoside Re, and prosapogenin E1, E2 and E3 from ginsenoside Rb1 by the acid treatment under physiological condition such as 37°C incubation in 0.1 N HCl. 2. The chemical structures of the artifact substances were determined by the analysis of CMR and mass spectra of TMS-derivatives as following;

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Authors and Affiliations

  1. Nautral Products Research Institute, Seoul National University, 110, Seoul, Korea

    Byung Hoon Han, Myung Hwan Park, Lin Keun Woo & Shoji Yahara

  2. Department of Chemistry, College ot Natural Science, Kangweon National University, 200, Chuncheon, Korea

    Yong Nam Han

  3. The Faculty of Pharmacy, The University of Tokyo, Japan

    Ushio Sankawa

  4. Institute of Pharmaceutical Sciences, School of Medicine, Hiroshima University, Hiroshima, Japan

    Osamu Tanaka

Authors
  1. Byung Hoon Han
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  2. Myung Hwan Park
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  3. Yong Nam Han
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  4. Lin Keun Woo
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  5. Ushio Sankawa
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  6. Shoji Yahara
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  7. Osamu Tanaka
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Han, B.H., Park, M.H., Han, Y.N. et al. The transformation of ginsenosides by acid catalysis in gastric pH. Arch. Pharm. Res. 4, 25–31 (1981). https://doi.org/10.1007/BF02856438

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  • DOI: https://doi.org/10.1007/BF02856438

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