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Moclobemide in the treatment of hot flashes in postmenopausal women

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Abstract

This randomized, prospective, double-blind study evaluated the efficacy and tolerability of moclobemide, a reversible, selective inhibitor of monoamine oxidase-A, in reducing the frequency and severity of hot flashes. Thirty post-menopausal women were enrolled, and 28 were allocated to 5 weeks of treatment with moclobemide 150 mg (group 1, n = 10), moclobemide 300 mg (group 2, n = 11), or placebo (group 3, n = 9). Data on hot flashes were recorded in a daily diary. Mean reductions in the hot flash severity score were 24.4% in the placebo group, 69.8% in group 1, and 35.0% in group 2. This large difference suggests that the beneficial effects were not due to a placebo effect. Moclobemide may be a new nonhormonal option for reducing the incidence, severity, and duration of hot flashes in postmenopausal women who do not wish to take estrogen or have contraindications to its use.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Başkent University Faculty of Medicine, Seyhan-Adana, Turkey

    Ebru Tarim M.D., Tayfun Bagis M.D., Esra Kilicdag M.D., Serkan Erkanli M.D., Erdogan Aslan M.D. & Esra Kuscu M.D.

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  1. Ebru Tarim M.D.
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  2. Tayfun Bagis M.D.
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  3. Esra Kilicdag M.D.
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  5. Erdogan Aslan M.D.
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  6. Esra Kuscu M.D.
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Tarim, E., Bagis, T., Kilicdag, E. et al. Moclobemide in the treatment of hot flashes in postmenopausal women. Adv Therapy 19, 258–265 (2002). https://doi.org/10.1007/BF02853171

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