Advances in Therapy

, Volume 17, Issue 3, pp 152–158 | Cite as

Correlation betweenHelicobacter pylori infection and gastrointestinal symptoms in pregnancy

  • Chun-Ying Wu
  • Jenn-Jhy Tseng
  • Min-Min Chou
  • Sheng-Kai Lin
  • Sek-Kwang Poon
  • Gran-Hum Chen


Nausea, vomiting, and other dyspeptic symptoms are common in pregnancy. This hospital-based, cross-sectional study was designed to determine the role ofHelicobacter pylori infection in gastrointestinal (GI) symptoms during pregnancy. Standardized verbal scales were used to evaluate the frequency and severity of GI symptoms in 54 women whose pregnancies were in the first 16 gestational weeks.H. pylori infection was defined as a positive serum immunoglobulin G result on an immunochromatographic assay. TheH. pylori seropositivity rate was higher in the pregnant women (69%) than in the general population (∼50%–55%), but seropositivity did not correlate with clinical symptoms. Moreover, no specific patterns of GI symptoms were uncovered in theH. pylori infected patients. Maternal age, body weight, parity, gestational week, and educational level were not associated withH. pylori infection; neither were the prevalence and severity of GI symptoms.


Helicobacter pylori pregnancy symptom dyspepsia 


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  1. 1.
    Klebanoff MA, Koslowe PA, Kaslow R, Rhoads GG. Epidemiology of vomiting in early pregnancy.Obstet Gynecol. 1985;66:612–616.PubMedGoogle Scholar
  2. 2.
    Tierson FD, Olsen CL, Hook EB. Nausea and vomiting of pregnancy and association with pregnancy outcome.Am J Obstet Gynecol. 1986;155:1017–1022.PubMedGoogle Scholar
  3. 3.
    Katz PO, Castell DO. Gastroesophageal reflux disease during pregnancy.Gastroenterol Clin North Am. 1998;27:153–167.PubMedCrossRefGoogle Scholar
  4. 4.
    Mayer IE, Hamid H. Abdominal pain during pregnancy.Gastroenterol Clin North Am. 1998; 27:1–36.PubMedCrossRefGoogle Scholar
  5. 5.
    Van Theil DH, Gavaler JS, Joshi SN, Sara RK, Stremple J. Heartburn of pregnancy.Gastroenterology. 1977;72:666–668.Google Scholar
  6. 6.
    Fairweather DV. Nausea and vomiting in pregnancy.Am J Obstet Gynecol. 1968;102:135–175.PubMedGoogle Scholar
  7. 7.
    Deuchar N. Nausea and vomiting in pregnancy: a review of the problem with particular regard to psychological and social aspects.Br J Obstet Gynaecol. 1995;102:6–8.PubMedGoogle Scholar
  8. 8.
    Depue RH, Berstein L, Ross RK, Judd HL, Henderson BE. Hyperemesis gravidarum in relation to estradiol levels, pregnancy outcome, and other maternal factors: a seroepidemiologic study.Am J Obstet Gynecol. 1987;156:1137–1141.PubMedGoogle Scholar
  9. 9.
    Brock-utne JG, Dow TGB, Dimopoulos GE, Welman S, Downing JW, Moshal MG. Gastric and lower esophageal sphincter (LES) pressures in early pregnancy.Br J Anaesth. 1981;53:381–384.PubMedCrossRefGoogle Scholar
  10. 10.
    Riezzo G, Pezzolla F, Darconza G, Diorgio I. Gastric myoelectrical activity in the first trimester of pregnancy: a cutaneous electrogastrographic study.Am J Gastroenterol. 1992;87:702–707.PubMedGoogle Scholar
  11. 11.
    Whitehead EM, Smith M, O’Sullivan G. Forum: an evaluation of gastric emptying times in pregnancy and the puerperium.Anaesthesia. 1993;48:53–57.PubMedCrossRefGoogle Scholar
  12. 12.
    Baron TH, Ramirez B, Richter JE. Gastrointestinal motility disorders during pregnancy.Ann Intern Med. 1993;118:336–375.Google Scholar
  13. 13.
    Frigo P, Lang C, Reisenberger K, Kolbl H, Hirschl AM. Hyperemesis gravidarum associated withH. pylori seropositivity.Obstet Gynecol. 1998;91:615–617.PubMedCrossRefGoogle Scholar
  14. 14.
    Vaira D, Holton J, Menegatti M, et al. Blood tests in the management ofHelicobacter pylori infection.Gut. 1998;43:S39-S46.PubMedGoogle Scholar
  15. 15.
    Lin JT, Wang JT, Wang TH, Wu MS, Lee TK, Chen CJ.Helicobacter pylori infection in a randomly selected population, healthy volunteers, and patients with gastric ulcer and gastric adenocarcinoma.Scand J Gastroenterol. 1993;28:1067–1072.PubMedCrossRefGoogle Scholar
  16. 16.
    Su YC, Wang WM, Chen LT, et al. High seroprevalence of IgG againstHelicobacter pylori among endoscopists in Taiwan.Dig Dis Sci. 1996;41:1571–1576.PubMedCrossRefGoogle Scholar
  17. 17.
    Lin JT, Wang LY, Wang JT, Wang TH, Chen CJ. Ecological study of association betweenH. pylori infection and gastric cancer in Taiwan.Dig Dis Sci. 1995;40:385–388.PubMedCrossRefGoogle Scholar
  18. 18.
    Tucci A, Corinaldesi R, Stanghellini V, et al.Helicobacter pylori infection and gastric function in patients with chronic idiopathic dyspepsia.Gastroenterology. 1992;103:768–774.PubMedGoogle Scholar
  19. 19.
    Loffeld RJLF, Potters HVPJ, Stobberingh F, Flendrig JA, Van Spreeuwel JD, Arends JW.Campylobacter associated gastritis in patients with non-ulcer dyspepsia: a double blind placebo controlled trial with colloid bismuth subcitrate.Gut. 1989;30:1206–1212.PubMedCrossRefGoogle Scholar
  20. 20.
    Pieramico O, Distchuneit H, Malfertheiner P. Gastrointestinal motility in patients with non-ulcer dyspepsia: a role forHelicobacter pylori infection?Am J Gastroenterol. 1993;88:364–368.PubMedGoogle Scholar
  21. 21.
    Mearin F, Ribot XD, Balboa B, et al. DoesHelicobacter pylori infection increase gastric sensitivity in functional dyspepsia?Gut. 1995;37:47–51.PubMedCrossRefGoogle Scholar
  22. 22.
    Wegener M, Borsch G, Schaffstein J. Are dyspeptic symptoms in patients withCampylobacter pylori-associated type B gastritis linked to delayed gastric emptying?Am J Gastroenterol. 1988; 83:737–740.PubMedGoogle Scholar
  23. 23.
    Armstrong D.Helicobacter pylori infection and dyspepsia.Scand J Gastroenterol. 1996;31(suppl 215): 38–47.CrossRefGoogle Scholar
  24. 24.
    Veldhuyzen Van ZantenSJO. The role ofHelicobacter pylori infection in non-ulcer dyspepsia.Aliment Pharmacol Ther. 1997;11(suppl 1):63–69.PubMedCrossRefGoogle Scholar
  25. 25.
    Talley NJ, Hunt RH. What role doesHelicobacter pylori play in dyspepsia and non-ulcer dyspepsia? Arguments for and againstH. pylori being associated with dyspeptic symptoms.Gastroenterology. 1997;113:S67-S77.PubMedCrossRefGoogle Scholar
  26. 26.
    Rothenbacher D, Peter R, Bode G, Adler G, Brenner H. Dyspepsia in relation toHelicobacter pylori infection and psychosocial work stress in white collar employees.Am J Gastroenterol. 1998;93:1443–1449.PubMedCrossRefGoogle Scholar
  27. 27.
    Blecker U, Lanciers S, Vandenplas Y. Evolution ofHelicobacter pylori positivity in infants born from positive mothers.J Pediatr Gastroenterol Nutr. 1994;19:87–90.PubMedCrossRefGoogle Scholar

Copyright information

© Health Communications Inc 2000

Authors and Affiliations

  • Chun-Ying Wu
    • 1
  • Jenn-Jhy Tseng
    • 2
  • Min-Min Chou
    • 2
  • Sheng-Kai Lin
    • 2
  • Sek-Kwang Poon
    • 3
  • Gran-Hum Chen
    • 3
  1. 1.Section of Gastroenterology Department of Internal MedicineTaichung Veterans General Hospital China Medical CollegeTaichungTaiwan, R.O.C.
  2. 2.Division of Maternal-Fetal Medicine Department of Obstetrics and GynecologyTaichung Veterans General HospitalTaichungTaiwan, R.O.C.
  3. 3.Section of Gastroenterology Department of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan, R.O.C.

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