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Relationship between cell proliferation and apoptosis in cervical carcinoma

  • Original Articles
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The Chinese-German Journal of Clinical Oncology

Abstract

Objective

To study the relationship between cell proliferation and apoptosis in cervical carcinoma and its clinical significance.

Methods

The cell proliferation and apoptosis of cervical epithelial cells in archival formalin-fixed, paraffin-embedded tissue sections of normal cervix, cervical intraepithelial neoplasms (CIN) and cervical squamous carcinoma were tested by using immunohistochemistry assay and DNA nick end-labeling technigue. The proliferation index (PI) and apoptosis index (AI) were calculated and their correlation with clinical and pathological data was analyzed.

Results

PI was gradually increased, but the AI and AI/PI ratio decreased from normal cervical epithelium, CIn to cervical carcinoma. There was no significant relationship among cell proliferation, apoptosis, clinical stages and pathological grades. High AI was always associated with a poor prognosis of the patients.

Conclusion

Cell proliferation and apoptosis allow to distinguish among normal epithelium, CIN and cervical carcinoma and are useful for the assessment of the malignant potential of tumor tissues.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Shanghai Sixth People's Hospital, 200233, Shanghai, China

    Xue Yuezhen

  2. Obstetrics and Gynecology Hospital, Shanghai Medical University, 200011, Shanghai, China

    Feng Youji, Zhu Guanzhen & Zhang Xiying

Authors
  1. Xue Yuezhen
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  2. Feng Youji
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  3. Zhu Guanzhen
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  4. Zhang Xiying
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Xue, Y., Feng, Y., Zhu, G. et al. Relationship between cell proliferation and apoptosis in cervical carcinoma. Chin. -Ger. J. Clin. Oncol. 1, 102–103 (2002). https://doi.org/10.1007/BF02851745

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  • DOI: https://doi.org/10.1007/BF02851745

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