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Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: A review of 5 clinical studies

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Abstract

Extracts from the seed of the horse chestnut (Aesculus hippocastanum L.) have traditionally been used to treat patients with chronic venous insufficiency and to alleviate its associated symptoms, including lower leg swelling. The efficacy of preparations that contain horse chestnut seed extract (HCSE) is believed to be due largely to an inhibitory effect on the catalytic breakdown of capillary wall proteoglycans. Aesculaforce® is a fresh plant HCSE that is available as an oral tincture, as tablets (20 mg or 50 mg), and as topical gel. Four clinical trials in patients with chronic venous insufficiency and 1 study in patients with varicose veins demonstrated the effectiveness of these preparations through the objective measure of reduction in lower leg edema and the subjective alleviation of leg pain, heaviness, and itching. Safe, well tolerated, and acceptable to patients, the fresh plant HCSE preparation Aesculaforce offers a real alternative in the treatment of patients with mild to moderate venous insufficiency.

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References

  1. World Health Organization.WHO Monographs on Selected Medicinal Plants. Geneva, Switzerland: WHO; 2002.

    Google Scholar 

  2. Eberhardt RT, Raffetto JD. Chronic venous insufficiency.Circulation. 2005; 111: 2398–2409.

    Article  PubMed  Google Scholar 

  3. Evans CJ, Fowkes FG, Ruckley CV, Lee AJ. Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study.J Epidemiol Community Health. 1999; 53: 149–153.

    Article  PubMed  CAS  Google Scholar 

  4. Kreysel HW, Nissen HP, Enghofer E. Erhöte Serumaktivitäten lysosomaler Enzyme bei Varikosis. Beeinflussung durch einen Rosskastaniensamenextrakt.Therapiewoche. 1983; 33: 1098–1104.

    Google Scholar 

  5. Kreysel HW, Nissen HP, Enghofer E. A possible role of lysosomal enzymes in the pathogenesis of varicosis and the reduction in their serum activity by Venostasin.VASA. 1983; 4: 377–382.

    Google Scholar 

  6. Enghofer E, Seibel K, Hammersen F. Die antiexsudative Wirkung von Rosskastaniensamenextrakt. Neue Ergebnisse zu ihrem Mechanismus.Therapiewoche. 1984; 34: 4130–4144.

    Google Scholar 

  7. Cebo B, Krupinska H, Mazur J, Czarnecki R. Pharmacological properties of saponin fractions obtained from domestic crude drugs:Saponaria officinalis, Primula officinalis andAesculus hippocastanum. Herba Polonica. 1976; 22: 154–162.

    CAS  Google Scholar 

  8. Damas P, Volon G, Damas J, Lecomte J. Sur l’action antioedème de l’escine.Bull Soc Roy Sci Liège. 1976; 45: 436–442.

    CAS  Google Scholar 

  9. Klemm J. Strömungsgeschwindigkeit von Blut in varikösen Venen der unteren Extremitäten. Einfluss eines Venentherapeutikums (Venostasin).München Med Wechenschr. 1982; 124: 579–582.

    CAS  Google Scholar 

  10. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency.Cochrane Database Syst Rev. 2004; 2: CD003230.

    PubMed  Google Scholar 

  11. Kalbfleisch W, Pfalzgraf H. Oedemprotektiva: äquipotente Dosierung: Rosskastanienextrakt und 0-β-hydroxyethylrutoside im Vergleich.Therapiewoche. 1989; 39: 3703–3707.

    Google Scholar 

  12. Rehn D, Unkauf M, Klein P, Jost V, Lücker PW. Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency.Arzneimittelforschung. 1996; 46: 483–487.

    PubMed  CAS  Google Scholar 

  13. Erler M. Rosskastaniensamenextrakt bei Therapie peripherer venöser Oedeme: ein klinischer Therapievergleich.Med Welt. 1991; 42: 593–596.

    Google Scholar 

  14. Diehm C, Trampisch HJ, Lange S, Schmidt C. Comparison of leg compression stocking and oral horse chestnut seed extract therapy in patients with chronic venous insufficiency.Lancet. 1996; 347: 292–294.

    Article  PubMed  CAS  Google Scholar 

  15. European Scientific Cooperative of Phytotherapy.Medicinal Uses of Plant Drugs. Exeter, Devon, UK: ESCOP; 1999.

    Google Scholar 

  16. Shah D, Bommer S, Degenring FH. Aesculaforce bei chronisch venöser Insuffizienz. Placebokontrollierte Doppelblind-Studie zum Nacjweis der Wirksamkeit und Verträglichkeit eines Phytotherapeutikums.Schweiz Z Ganzheitsmed. 1997; 9: 86–91.

    Google Scholar 

  17. Dickson S, Gallagher J, McIntyre L, Suter A, Tan J. An open study to assess the safety and efficacy ofAesculus hippocastanum tablets (Aesculaforce 50 mg) in the treatment of chronic venous insufficiency.J Herbal Pharmacother. 2004; 4: 19–32.

    Article  Google Scholar 

  18. Geissbühler S, Degenring FH. Treatment of chronic venous insufficiency with Aesculaforce vein gel.Schweiz Z Ganzheitsmed. 1999; 11: 82–87.

    Google Scholar 

  19. Pilz E. Ödeme bei Venenerkrankungen.Med Welt. 1990; 41: 1143–1144.

    Google Scholar 

  20. Rudofsky G. Ödemprotektive Wirkung und klinische Wirksamkeit von Rosskastaniensamenextrakt im Doppelblindversuch.Fortschr Med. 1986; 104: 47–48.

    Google Scholar 

  21. Erdlen F. Klinische Wirksamkeit von Venostasin retard im Doppelblindversuch.Med Welt. 1989; 40: 994–996.

    Google Scholar 

  22. Siebert U, Brach M, Srocyzynski G, Uberla K. Efficacy, routine effectiveness and safety of horsechestnut seed extract in the treatment of chronic venous insufficiency.Int Angiol. 2002; 21: 305–315.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Medical Department, Bioforce AG, Switzerland

    Andy Suter MSc (Head)

  2. Abt. Medizin, Bioforce AG, Grünaustrasse, CH-9325, Roggwil, Switzerland

    Silvia Bommer MD (Head)

  3. Department of Surgery, Hospital Alstätten, Altstätten, Switzerland

    Jordan Rechner MD (Head)

Authors
  1. Andy Suter MSc
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  2. Silvia Bommer MD
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  3. Jordan Rechner MD
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Suter, A., Bommer, S. & Rechner, J. Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: A review of 5 clinical studies. Adv Therapy 23, 179–190 (2006). https://doi.org/10.1007/BF02850359

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