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Primary functioning hepatic paraganglioma: A case report

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Abstract

An extra-adrenal pheochromocytoma is known as a paraganglioma. This report describes a patient with a rare primary functioning hepatic paraganglioma that resulted in hypertension. Computed tomography showed a highly vascular lesion located in segment 6 of the liver; it measured 6 x 5.5 cm. A right hemihepatectomy was subsequently performed; this was followed by an uneventful recovery and the disappearance of hypertension. The imaging characteristics and therapeutic principles of this rare tumor were gleaned from a review of the literature. Identification of this malignant tumor or possible recurrence is difficult, so longterm follow-up is recommended.

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References

  1. Whalen RK, Althausen AF, Daniels G. Extra-adrenal pheochromocytoma.J Urol. 1992; 147: 1–10.

    PubMed  CAS  Google Scholar 

  2. Jaeck D, Paris F, Welsch M, et al. Primary hepatic pheochromocytoma: a second case.Surgery. 1995; 117: 586–590.

    Article  PubMed  CAS  Google Scholar 

  3. Reif MC, Hanto DW, Moulton JS, Alspaugh JP, Bejarano P. Primary hepatic pheochromocytoma?Am J Hypertens. 1996; 9: 1040–1043.

    Article  PubMed  CAS  Google Scholar 

  4. D’Errico A, Pierangeli F, Fiorentino M, Altimari A, Grigioni WF. Primary paraganglioma strictly confined to the liver and mimicking hepatocellular carcinoma.Am J Surg Pathol. 2002; 26: 945–949.

    Article  PubMed  Google Scholar 

  5. Tanaka S, Ito T, Tomoda J, Higashi T, Yamada G, Tsuji T. Malignant pheochromocytoma with hepatic metastasis diagnosed 20 years after resection of the primary adrenal lesion.Intern Med. 1993, 32: 789–794.

    Article  PubMed  CAS  Google Scholar 

  6. Ichikawa T, Federle MP, Grazioli L, Madariag J, Nalesnik M, Marsh W. Fibrolamellar hepatocellular carcinoma: imaging and pathologic finding in 31 recent cases.Radiology. 1999; 213: 352–361.

    PubMed  CAS  Google Scholar 

  7. Mozley PD, Kim CK, Mohsin J, Jatlow A, Gosfield E III, Alavi A. The efficacy of iodine-123-MIBG as a screening test for pheochromocytoma.J Nucl Med. 1994, 35: 1138–1144.

    PubMed  CAS  Google Scholar 

  8. Eisenhofer G, Bornstein SR, Brouwers FM, et al. Malignant pheochromocytoma: current status and initiatives for future progress.Endocr Relat Cancer. 2004; 11: 423–436.

    Article  PubMed  CAS  Google Scholar 

  9. Ilias I, Pacak K. Anatomical and functional imaging of metastatic pheochromocytoma.Ann N Y Acad Sci. 2004; 1018: 495–504.

    Article  PubMed  CAS  Google Scholar 

  10. Pacak K, Eisenhofer G, Carrasquillo JA, Chen CC, Li ST, Coldstein DS. 6-[18F] fluorodopamine positron emission tomographic (PET) scanning for diagnostic localization of pheochromocytoma.Hypertension. 2001; 38: 6–8.

    PubMed  CAS  Google Scholar 

  11. Quiros RM, Kim AW, Maxhimer J, Gattuso P, Xu X, Prinz RA. Differential heparanase-1 expression in malignant and benign pheochromocytomas.J Surg Res. 2002; 108: 44–50.

    Article  PubMed  CAS  Google Scholar 

  12. Gimenez-Roqueplo AP, Favier J, Rustin P, et al. Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas.Cancer Res. 2003; 63: 5615–5621.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Shandong Provincial Hospital School of Medicine Shandong University Jinan, Shandong, P. R. China

    Hong Chang MD

  2. Department of Gastroenterology, Department of Surgery, Shandong Provincial Hospital School of Medicine Shandong University Jinan, Shandong, P. R. China

    Lin Xu MD

  3. Department of Surgery, Shandong Provincial Hospital School of Medicine Shandong University Jinan, Shandong, P. R. China

    Qingling Mu MD

Authors
  1. Hong Chang MD
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  2. Lin Xu MD
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  3. Qingling Mu MD
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Chang, H., Xu, L. & Mu, Q. Primary functioning hepatic paraganglioma: A case report. Adv Therapy 23, 817–820 (2006). https://doi.org/10.1007/BF02850323

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  • DOI: https://doi.org/10.1007/BF02850323

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