Advances in Therapy

, Volume 23, Issue 6, pp 957–973 | Cite as

Endometrial apoptosis induced by a 900-MHz mobile phone: Preventive effects of vitamins E and C

  • Baha Oral
  • Mehmet Guney
  • Fehmi Ozguner
  • Nermin Karahan
  • Tamer Mungan
  • Selcuk Comlekci
  • Gokhan Cesur


Numerous reports have described the effects induced by an electromagnetic field (EMF) in various cellular systems. The purposes of this study were to examine oxidative stress that promotes production of reactive oxygen species induced by a 900-megahertz (MHz) mobile phone and the possible ameliorating effects of vitamins E and C on endometrial tissue against EMF-induced endometrial impairment and apoptosis in rats. Animals were randomly grouped as follows: (1) sham-operated control group (n=8), (2) 900 MHz EMF-exposed group (n=8; 30 min/d for 30 d), and (3) 900 MHz EMF-exposed group, treated with vitamins E and C (n=8; 50 mg/kg intramuscularly and 20 mg/kg body weight intraperitoneally before daily EMF exposure). Malondialdehyde (an index of lipid peroxidation) was used as a marker of oxidative stress-induced endometrial impairment; Bcl-2, Bax, caspase-3, and caspase-8 were assessed immunohistochemically. In this study, increased malondialdehyde levels in endometrial tissue and apoptosis illustrated the role of the oxidative mechanism induced by exposure to a 900-MHz mobile phone-like device and vitamins E and C; via free radical scavenging and antioxidant properties, oxidative tissue injury and apoptosis were ameliorated in rat endometrium. In conclusion, exposure to 900-MHz radiation emitted by mobile phones may cause endometrial apoptosis and oxidative stress, but treatment with vitamins E and C can diminish these changes and may have a beneficial effect in preventing endometrial changes in rats.


apoptosis endometrium mobile phone oxidative stress vitamin C vitamin E 


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Copyright information

© Health Communications Inc 2006

Authors and Affiliations

  • Baha Oral
    • 1
  • Mehmet Guney
    • 1
  • Fehmi Ozguner
    • 2
  • Nermin Karahan
    • 3
  • Tamer Mungan
    • 4
  • Selcuk Comlekci
    • 5
  • Gokhan Cesur
    • 2
  1. 1.Department of Obstetrics and GynecologySuleyman Demirel UniversityIspartaTurkey
  2. 2.Department of Physiology Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey
  3. 3.Department of Pathology Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey
  4. 4.Department of Obstetrics and GynecologyFaculty of MedicineIspartaTurkey
  5. 5.Department of Electronics and CommunicationFaculty of EngineeringIspartaTurkey

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