Skip to main content
SpringerLink
Log in

Response to travoprost in black and nonblack patients with open-angle glaucoma or ocular hypertension

  • Published:
Advances in Therapy Aims and scope Submit manuscript

Abstract

Two prospective, controlled, multicenter, double-masked studies—one lasting 6 months (n=594) and the other, 12 months (n=787)—examined the intraocular pressure (IOP)-lowering efficacy of travoprost in 1381 black and nonblack patients with open-angle glaucoma or ocular hypertension. Investigated regimens were travoprost 0.004% once daily, latanoprost 0.005% once daily, and timolol 0.5% twice daily. In both studies, mean IOP was significantly lower in blacks treated with travoprost. The IOP reduction was also significantly greater in blacks after adjustments for age, sex, iris color, diagnosis, and corneal thickness. Timolol lowered mean IOP to a greater extent in nonblack patients. The significantly larger IOP reduction with travoprost compared with timolol in both racial groups was more pronounced in blacks. Travoprost also was superior to latanoprost in blacks. Mean changes from baseline generally were greater for black than for nonblack patients, although the differences did not achieve statistical significance. The response rate to travoprost was higher in blacks. The most common adverse effect was hyperemia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Sommer A, Tielsch JM, Katz J, et al. Racial differences in the cause-specific prevalence of blindness in East Baltimore.N Engl J Med. 1991;325:1412–1417.

    Article  PubMed  CAS  Google Scholar 

  2. Hiller R, Kahn HA. Blindness from glaucoma.Am J Ophthalmol. 1975;80:62–69.

    PubMed  CAS  Google Scholar 

  3. Wilson R, Richardson TM, Hertzmark E, Grant WM. Race as a risk factor for progressive glaucomatous damage.Ann Ophthalmol. 1985;17:653–659.

    PubMed  CAS  Google Scholar 

  4. Martin MJ, Sommer A, Gold EB, Diamond EL. Race and primary open-angle glaucoma.Am J Ophthalmol. 1985;99:383–387.

    PubMed  CAS  Google Scholar 

  5. Leske MC, Connell AM, Wu SY, Hyman LG, Schachat AP. Risk factors for open-angle glaucoma. The Barbados Eye Study.Arch Ophthalmol. 1995;113:918–924.

    PubMed  CAS  Google Scholar 

  6. Hellberg MR, Sallee VL, McLaughlin MA, et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist.J Ocul Pharmacol Ther. 2001;17:421–432.

    Article  PubMed  CAS  Google Scholar 

  7. Goldberg I, Cunha-Vaz J, Jacobsen JE, et al. Comparison of topical travoprost eye drops given once daily and timolol 0.5% given twice daily in patients with open-angle glaucoma or ocular hypertension.J Glaucoma. 2001;10:414–422.

    Article  PubMed  CAS  Google Scholar 

  8. Robertson SM, Sullivan EK, Silver LH, et al. Differences between black and non-black patients with open-angle glaucoma or ocular hypertension in IOP-lowering response to travoprost.Invest Ophthalmol Vis Sci. 2001;42:S559. Abstract 3004.

    Google Scholar 

  9. Netland PA, Landry T, Sullivan EK, et al. Travoprost compared with latanoprost and timolol in patients with open-angle glaucoma or ocular hypertension.Am J Ophthalmol. 2001;132:472–484.

    Article  PubMed  CAS  Google Scholar 

  10. Fellman RL, Sullivan EK, Ratliff M, et al. Comparison of travoprost 0.0015% and 0.004% with timolol 0.5% in patients with elevated intraocular pressure: a 6-month, masked, multicenter trial.Ophthalmology. 2002;109:998–1008.

    Article  PubMed  Google Scholar 

  11. Somova L, Mufunda J. Ethnic differences of renin-sodium profile and renal prostaglandins in the pathogenesis of systemic arterial hypertension.Cent Afr J Med. 1996;42:170–175.

    PubMed  CAS  Google Scholar 

  12. LaRosa FA, Gross RL, Orengo-Nania S. Central corneal thickness of Caucasians and African Americans in glaucomatous and nonglaucomatous populations.Arch Ophthalmol. 2001;119: 23–27.

    CAS  Google Scholar 

  13. Brandt JD, Beiser JA, Kass MA, Gordon MO. Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS).Ophthalmology. 2001;108:1779–1788.

    Article  PubMed  CAS  Google Scholar 

  14. Katz IM, Berger ET. Effects of iris pigmentation on response of ocular pressure to timolol.Surv Ophthalmol. 1979;23:395–398.

    Article  PubMed  CAS  Google Scholar 

  15. Saliminen L, Imre G, Huupponen R. The effect of ocular pigmentation on intraocular pressure response to timolol.Acta Ophthalmol. 1985;63(suppl):15–18.

    Google Scholar 

  16. Netland PA, Schwartz B, Feke GT, Takamoto T, Konno S, Goger DG. Diversity of response of optic nerve head circulation to timolol maleate in gel-forming solution.J Glaucoma. 1999;8: 164–171.

    Article  PubMed  CAS  Google Scholar 

  17. Wilensky JT, Gandhi N, Pan T. Racial influence in open angle glaucoma.Ann Ophthalmol. 1978; 10:1398–1402.

    PubMed  CAS  Google Scholar 

  18. Grant WM, Burke JF. Why do some people go blind from glaucoma?Ophthalmology. 1982;89: 991–998.

    PubMed  CAS  Google Scholar 

  19. Tielsch JM, Sommer A, Katz J, Royall RM, Quigley HA, Javitt J. Racial variations in the prevalence of open-angle glaucoma. The Baltimore Eye Study.JAMA. 1991;266:369–374.

    Article  PubMed  CAS  Google Scholar 

  20. Wilson MR, Hertzmark E, Walker AM, Childs-Shaw K, Epstein DL. A case-control study of risk factors in open angle glaucoma.Arch Ophthalmol. 1987;105:1066–1071.

    PubMed  CAS  Google Scholar 

  21. Schwartz AL, Love DC, Schwartz MA. Long-term follow-up of argon laser trabeculoplasty for uncontrolled open-angle glaucoma.Arch Ophthalmol. 1985;103:1482–1484.

    PubMed  CAS  Google Scholar 

  22. Shingleton BJ, Distler JA, Baker BH. Filtration surgery in black patients. Early results in a West Indian population.Ophthalmic Surg. 1987;18:195–199.

    PubMed  CAS  Google Scholar 

  23. Berson D, Zauberman H, Landau L. Filtering operation in Africans.Am J Ophthalmol. 1969;67: 395–398.

    PubMed  CAS  Google Scholar 

  24. Freedman J, Shen E, Aherens M. Trabeculectomy in a black American glaucoma population.Br J Ophthalmol. 1976;60:573–574.

    Article  PubMed  CAS  Google Scholar 

  25. The AGIS Investigators. The Advanced Glaucoma Intervention Study (AGIS): 4. Comparison of treatment outcomes within race. Seven-year results.Ophthalmology. 1998;105:1146–1164.

    Article  Google Scholar 

  26. Merrit JC, Perry OD, Ellison PS, et al. Effects of pilocarpine in blacks with open angle glaucoma.Glaucoma. 1985;7:127–130.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, University of Tennessee Health Science Center, 956 Court Avenue, 38163, Memphis, TN

    Peter A. Netland MD, PhD & Michael V. W. Bergamini PhD

  2. Alcon Research, Ltd., Fort Worth, Texas

    Stella M. Robertson PhD, E. Kenneth Sullivan PhD, Lewis Silver PhD, Scott Krueger MS, Alan L. Weiner PhD & Alberta A. Davis PhD

Authors
  1. Peter A. Netland MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stella M. Robertson PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Kenneth Sullivan PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lewis Silver PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Michael V. W. Bergamini PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Scott Krueger MS
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Alan L. Weiner PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Alberta A. Davis PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

Travoprost Study Groups

Rights and permissions

Reprints and permissions

About this article

Cite this article

Netland, P.A., Robertson, S.M., Sullivan, E.K. et al. Response to travoprost in black and nonblack patients with open-angle glaucoma or ocular hypertension. Adv Therapy 20, 149–163 (2003). https://doi.org/10.1007/BF02850202

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02850202

Keywords

Search

Navigation