Skip to main content
Log in

Safety and efficacy ofEupatorium laevigatum paste as therapy for buccal aphthae: Randomized, double-blind comparison with triamcinolone 0.1% orabase

  • Published:
Advances in Therapy Aims and scope Submit manuscript


Eupatorium laevigatum Lam. is a plant common to the central region of Brazil, where it is a widely used remedy for lesions such as buccal aphthae. These painful inflammatory ulcers affect 50% of the general population. For the first part of this two-part study, a phytotherapeutic preparation fromE. laevigatum extracts was formulated into an orabase paste appropriate for use on the buccal mucosa. The study evaluated the toxicologic safety of this paste in 20 healthy volunteers, as determined by changes in biochemical and hematologic values and on urinalysis and intrabuccal examination. The second part of the study was a randomized, double-blind comparison of efficacy with triamcinolone 0.1% orabase in 60 patients. The healthy volunteers tolerated the phytotherapeutic paste well, and no adverse effects could be attributed to its use. In the clinical comparison, after 5 days of treatment, 40% of the patients who used the paste and 26.7% of those who used triamcinolone obtained complete cure of the ulcers. Pain was alleviated in 70% of the phytotherapeutic group and in 33.3% of the triamcinolone group. The phytotherapeutic paste ofE. laevigatum was a safe and effective treatment of buccal aphthae, the most common disease of the buccal mucosa

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others


  1. Correa P.Dicion→io das Plantas Úteis do Brasil. Rio de Janeiro: Instituto Brasileiro de Desenvolvimento Florestal; 1926.

  2. Barbosa AS, Schimiz PI. Ocupação indígena do Cerrado: esboço de uma história. In: Sano SM, Almeida SP, eds.Cerrado: Ambiente e Flora. Planaltina: Embrapa; 1998:3–43.

    Google Scholar 

  3. Callejo FJG, Alborch MHO, Ventura AM, Cortes PS, Algarra JM. Recurrent aphthous stomatitis and clinical response to pentoxyphylline.Acta Otorrinolaringol Esp. 1999;50:671–673.

    Google Scholar 

  4. Rhodus NL, Bereuter BA. An evaluation of a chemical cautery agent and an anti-inflammatory ointment for the treatment of recurrent aphthous stomatitis: a pilot study.Quintessence Int. 1998; 29:769–773.

    PubMed  CAS  Google Scholar 

  5. Matos FJA.Introdução a Fitoquimica Experimental. Fortaleza: Universidade Federal do Ceará; 1997.

    Google Scholar 

  6. Martindale W.The Extra Pharmacopoeia. London: Pharmaceutical Press; 1993.

    Google Scholar 

  7. Edres MAG, Scully C, Gelbier M. Use of proprietary agents to relieve recurrent aphthous stomatitis.Br Dent J. 1997;182:144–146.

    PubMed  CAS  Google Scholar 

  8. Simões CMO, Schenkel EP, Gosmann G, Mello JCP, Mentz LA, Petrovick PR.Farmacognosia: da Planta ao Medicamento. Porto Alegre: Universidade Federal do Rio Grande do Sul; 1999.

    Google Scholar 

  9. Clavin ML, Gorzalczany S, Mino J, et al. Antinociceptive effect of some Argentine medicinal species ofEupatorium. Phytother Res. 2000;14:275–277.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Filho, W.P., Ribeiro, J.E.G. & Pinto, D.S. Safety and efficacy ofEupatorium laevigatum paste as therapy for buccal aphthae: Randomized, double-blind comparison with triamcinolone 0.1% orabase. Adv Therapy 17, 272–281 (2000).

Download citation

  • Issue Date:

  • DOI: