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Cholesterol-lowering effects of a new isolated soy protein with high levels of nondenaturated protein in hypercholesterolemic patients

Advances in Therapy volume 24, pages 439–447 (2007)Cite this article

Abstract

This study was undertaken to compare the effects on plasma cholesterol concentration of a new isolated soy protein in which the protein structure is kept in its native, nondenaturated form (verum 1) versus a conventional isolated soy protein (verum 2) and milk protein (placebo). This prospective, randomized, double-blind, placebo-controlled study was conducted in an outpatient clinical study center in Berlin, Germany. Over 8 wk, 120 patients (total cholesterol, 5.2–7.8 mmol/L) were given verum 1, verum 2, or placebo at a dosage of 25 g protein daily. At the end of the treatment period, total cholesterol levels were significantly reduced by 10.7% in the verum 1 group compared with placebo (P < .001), and levels were reduced by 5.8% in the verum 2 group (P=.008). The difference between the 2 verum groups was statistically significant (P=.008). Low-density lipoprotein cholesterol levels were significantly reduced with nondenaturated isolated soy protein only: levels were reduced by 9.4% in the verum 1 group (P=.002) and by 4.9% in the verum 2 group (P=.107). Again, the difference between the verum groups was significant (P=.05). The results of this study confirm that supplementation with isolated soy protein can lead to significant reductions in plasma concentrations of total and low-density lipoprotein cholesterol. These reductions are significantly more pronounced with an isolated soy protein that maintains the native protein structure than with a commercially available reference isolated soy protein.

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Affiliations

  1. Prof, c/o A Sjoholm, VO Internmedicin, Sodersjukhuset Karolinska Institute, 118 83, Stockholm, Sweden

    L. H. Hoie MD, M. Guldstrand MD, PhD & A. Sjoholm MD, PhD

  2. Phytopharm Research, Berlin, Germany

    H. J. Graubaum PhD & J. Gruenwald PhD

  3. Prof, Institute for Nutritional Science, University of Potsdam, Potsdam, Germany

    H. J. F. Zunft PhD

  4. Prof, German Institute of Human Nutrition, Bergholz-Rehbruecke, Germany

    H. J. F. Zunft PhD & W. Lueder PhD

Authors
  1. L. H. Hoie MD
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  2. M. Guldstrand MD, PhD
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  3. A. Sjoholm MD, PhD
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  4. H. J. Graubaum PhD
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  5. J. Gruenwald PhD
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  6. H. J. F. Zunft PhD
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  7. W. Lueder PhD
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Correspondence to L. H. Hoie MD.

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Hoie, L.H., Guldstrand, M., Sjoholm, A. et al. Cholesterol-lowering effects of a new isolated soy protein with high levels of nondenaturated protein in hypercholesterolemic patients. Adv Therapy 24, 439–447 (2007). https://doi.org/10.1007/BF02849913

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  • DOI: https://doi.org/10.1007/BF02849913

Keywords

  • soy
  • isolated soy protein
  • protein structure
  • denaturation
  • cholesterol reduction
  • soy peptides