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The effect of hepatic blood inflow occlusion on hepatic cancer treated with diode-laser thermocoagulation

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Abstract

Objective: To assess the effect of temporary occlusion of hepatic blood inflow on hepatic cancer treated with diode-laser induced thermocogation (LITT). Methods: The carcinoma Walker-256 was implanted in 40 SD rat livers. Twelve days later, the animals were randomly divided into 4 groups. Group A received LITT alone; group B received hepatic artery temporary occlusion during LITT; group C received portal vein temporary occlusion during LITT; group D received hepatic artery and portal vein temporary occlusion during LITT. Tumors were exposed to 810 nm diode-laser light at 0.95 watts for 10 min, from a scanner tip applicator placed in the tumor. At the same time, the intrahepatic temperature distribution in rats with liver tumors was measured per 2 min during thermocoagulation. Tumor control was examined immediately 7 and 14 d after thermocoagulation. Results: There was significant difference of intrahepatic temperature distribution in rats with liver tumors among the 4 groups (P<0.05) except when group C samples were compared with group D samples at each time point, and group B samples were compared with group C samples at 120 s (P>0.05). Light microscopic examination of the histologic section samples revealed three separate zones: regular hyperthermic coagulation necrosis zone, transition zone and reference zone. Compared with the samples in group A and group B, group C and group D samples had more clear margin among the three zones. Conclusion: The hepatic blood inflow occlusion, especially portal vein hepatic blood inflow occlusion, or all hepatic blood inflow occlusion considerably increased the efficacy of LITT in the treatment of liver cancer.

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Authors and Affiliations

  1. Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 310016, Hangzhou, China

    Hong De-fei, Chen Bin & Peng Shu-you

  2. Department of Pathology, School of Medicine, Zhejiang University, 310006, Hangzhou, China

    Li Song-ying

  3. State Key Laboratory of Silicon Marterial, Zhejiang University, 310027, Hangzhou, China

    Tong Li-min

Authors
  1. Hong De-fei
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  2. Li Song-ying
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  3. Tong Li-min
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  4. Chen Bin
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  5. Peng Shu-you
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Additional information

Project supported by the National Basic Research and Development Program (973) (No. 863-410-2001-5) of China and Science Foundation of Zhejiang Province (No. 2004C33016), China

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De-fei, H., Song-ying, L., Li-min, T. et al. The effect of hepatic blood inflow occlusion on hepatic cancer treated with diode-laser thermocoagulation. J Zheijang Univ Sci B 6, 232–235 (2005). https://doi.org/10.1007/BF02842457

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  • DOI: https://doi.org/10.1007/BF02842457

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