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In vitro study of immunosuppressive effect of apoptotic cells

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Abstract

Recent studies revealed that apoptotic cells are actively involved in immunosuppression and anti-inflammation. After being phagocytosed by macrophages, apoptotic cells can actively regulate cytokines secretion from lipopolysaccharide (LPS)-stimulated macrophages in which the secretion of immunosuppressive cytokines such as interleukin-10 (IL-10) is increased while the pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNFα), interleukin-1beta (IL-1β) and leukin-8 (IL-8) are suppressed. In this paper, we first present evidence that phagocytosed apoptotic cells regulate cytokine secretion of LPS-stimulated macrophages, but also inhibit the activation of T lymphocytes stimulated by ConA. These data suggest that apoptotic cells can alter the biological behavior of macrophages which gain immunosuppressive property.

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Authors and Affiliations

  1. Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, 310027, Hangzhou, China

    Zhang Wen-jin & Zheng Shu-sen

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  1. Zhang Wen-jin
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  2. Zheng Shu-sen
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Correspondence to Zheng Shu-sen.

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Project supported by the National Basic Research Program (973) of China (No. 2003CB515500) and the National Natural Science Foundation of China (No. 30371358)

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Wen-jin, Z., Shu-sen, Z. In vitro study of immunosuppressive effect of apoptotic cells. J. Zheijang Univ.-Sci. B 6, 919–925 (2005). https://doi.org/10.1007/BF02841004

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  • DOI: https://doi.org/10.1007/BF02841004

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