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Pharmacokinetics of mycophenolic acid in Chinese kidney transplant patients

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Abstract

To assess the influence of cyclosporin A (CsA) and tacrolimus (FK506) on mycophenolic acid (MPA) and correlation analysis of the pharmacokinetic parameters and patient characteristics, clinical outcome in Chinese kidney transplant recipients, the pharmacokinetics of 1000 mg mycophenolate mofetil (MMF) twice daily was measured by high-performance liquid chromatography (HPLC). PKS (Pharmaceutical Kinctics Software) 1.0.2 software package was used for the calculation of pharmacokinetic parameters. The meanC max,t max, and AUC(0–12) were (21.88±10.52) μg/ml, (1.20±0.95) h, and (52.546±13.215) μg·h/ml, respectively. The level of AUC(0–12) in the FK506 group was significantly higher than that in the CsA group. MPA appeared not to be affected by renal function. MPA AUC(0–12) showed statistically significant difference according to the patient's gender.

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References

  • Bullingham, R.E., Nicholls, A., Hale, M., 1996a. Pharmacokinetics of mycophenolate mofetil (RS61443): A short review.Transplant. Proc.,28(2):925–929.

    PubMed  CAS  Google Scholar 

  • Bullingham, R.E., Monroe, S., Nicholls, A., Hale, M., 1996b. Pharmacokinetics and bioavailability of mycophenolate mofetil in healthy subjects after single-dose oral and intravenous administration.J. Clin. Pharmacol.,36(4):315–324.

    PubMed  CAS  Google Scholar 

  • Bullingham, R.E., Nicholls, A.J., Kamm, B.R., 1998. Pharmacokinetics of mycophenolate mofetil.Clin. Pharmacokinet.,34(6):429–455.

    Article  PubMed  CAS  Google Scholar 

  • Cho, E.K., Han, D.J., Kim, S.C., Burckart, G.J., Venkataramanan, R., Oh, J.M., 2004. Pharmacokinetic study of mycophenolic acid in Korean kidney transplant patients.J. Clin. Pharmacol.,44(7):743–750.

    Article  PubMed  CAS  Google Scholar 

  • European Mycophenolate Mofetil Cooperative Study Group, 1995. Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection.Lancet.,345(8961):1321–1325.

    Google Scholar 

  • Filler, G., Zimmering, M., Mai, I., 2000. Pharmacokinetics of mycophenolate mofetil are influenced by concomitant immunosuppression.Pediatr. Nephrol.,14(2):100–104.

    Article  PubMed  CAS  Google Scholar 

  • Gregoor, P.J., de Sevaux, R.G., Henc, R.J., Hesse, C.J., Hilbrands, L.B., Vos, P., van Gelder, T., Hoitsma, A.J., Weimar, W., 1999. Effect of cyclosporine on mycophenolic acid trough levels in kidney transplant recipients.Transplantation,68(10):1603–1606.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, A.G., Rigby, R.J., Taylor, P.J., Jones, C.E., Allen, J., Franzen, K., Falk, M.C., Nicol, D., 1999. The kinetics of mycophenolic acid and its glucuronide metabolite in adult kidney transplant recipients.Clin. Pharmacol. Ther.,66(5):492–500.

    Article  PubMed  CAS  Google Scholar 

  • Kuriata-kordek, M., Boratynska, M., Falkiewicz, K., Porazko, T., Urbaniak, J., Wozniak, M., Patrzalek, D., Szyber, P., Klinger, M., 2003. The influence of calcineurin inhibitors on mycophenolic acid pharmacokinetics.Transplant. Proc.,35(6):2369–2371.

    Article  PubMed  CAS  Google Scholar 

  • Lee, H.J., Pawlak, K., Nguyen, B.T., Robinsm, R.K., Sadee, W., 1985. Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studies in mouse lymphoma cell culture.Cancer Res.,45:5512–5520.

    PubMed  CAS  Google Scholar 

  • Matsuzawa, Y., Nakase, T., 1984. Metabolic fate of ethyl O-[N-(p-carboxyphenyl)-carbamoyl] mycophenolate (CAM), a new antitumor agent, in experimental animals.J. Pharmacobiodyn.,7(10):776–783.

    PubMed  Google Scholar 

  • Pescovitz, M.D., Guasch, A., Gaston, R., Rajagopalan, P., Tomlanovich, S., Weinstein, S., Bumgardner, G.L., Melton, L., Ducray, P.S., Banken, L.,et al., 2003. Equivalent pharmacokinetics of mycophenolate mofetil in African-American and Caucasian male and female stable renal allograft recipients.Am. J. Transplant.,3(12):1581–1586.

    Article  PubMed  CAS  Google Scholar 

  • Rasom, J.T., 1995. Mechanism of action of mycophenolate mofetil.Ther. Drug. Monit.,17(6):681–684.

    Google Scholar 

  • Shaw, L.M., Sollinger, H.W., Halloran, P., Morris, R.E., Yatscoff, R.W., Ransom, J., Tsina, I, Keown, P., Holt, D.W., Lieberman, R., 1995. Mycophenolate mofetil: A report of the consensus panel.Ther. Drug. Monit.,17(6):690–699.

    Article  PubMed  CAS  Google Scholar 

  • Shaw, L.M., Nicholl, A., Hale, M., Armstrong, V.W., Oellerich, M., Yatscoff, R., Morris, R.E., Holt, D.W., Venkataramanan, R., Haley, J.,et al., 1998. Therapeutic monitoring of mycophenolic acid: A consensus panel report.Clin. Biochem.,31(5):317–322.

    Article  PubMed  CAS  Google Scholar 

  • Shaw, L.M., Kaplan, B., DeNofrio, D., Korecka, M., Brayman, K.L., 2000. Pharmacokinetics and concentration-control investigations of mycophenolic acid in adults after transplantation.Ther. Drug. Monit.,22(1):14–19.

    Article  PubMed  CAS  Google Scholar 

  • Shaw, L.M., Pawinski, T., Korecka, M., Nawrocki, A., 2002. Monitoring of mycophenolic acid in clinical transplantation.Ther. Drug. Monit.,24(1):68–73.

    Article  PubMed  CAS  Google Scholar 

  • Takahashi, K., Ochiai, T., Uchida, K., Yasumara, T., Ishibashi, M., Suzuki, S., Otsubo, O., Isono, K., Takagi, H., Oka, T., 1995. Pilot study of mycophenolate mofetil (RS-61443) in the prevention of acute rejection following renal transplantation in Japanese patients. RS-61443 Investigation Committee-Japan.Transplant. Proc.,27(1): 1421–1424.

    PubMed  CAS  Google Scholar 

  • Tricontinental Mycophenolate Mofetil Renal Transplantation Study Group, 1996. A blinded, randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantation.Transplantation,61(7):1029–1037.

    Article  Google Scholar 

  • Young, C.J., Sollinger, H.W., 1994. RS-61443: A new immunosuppressive agent.Transplant. Proc.,26(6):3144–3146.

    PubMed  CAS  Google Scholar 

  • Zucker, K., Rosen, A., Tsaroucha, A., de Faria, L., Roth, D., Ciancio, G., Esquenazi, V., Burke, G., Tzakis, A., Miller, J., 1997. Unexpected augmentation of mycophenolic acid pharmacokinetics in renal transplant patients receiving tacrolimus and mucophenolate mofetil in combination therapy, an analogous in vitro findings.Transpl. Immunol.,5(3):225–232.

    Article  PubMed  CAS  Google Scholar 

  • Zucker, K., Tsaroucha, A., Olsen, L., Esquenazi, V., Tzakis, A., Miller, J., 1999. Evidence that tacrolimus augments the bioavailability of mycophenolate mofetil through the inhibition of mycophenolic acid glucuronidation.Ther. Drug. Monit.,21(1):35–43.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Pharmacology, First Affiliated Hospital, School of Medicine, Zhejiang University, 310003, Hangzhou, China

    Lu Xiao-yang, Huang Hong-feng, Sheng-Tu Jian-zhong & Liu Jian

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  1. Lu Xiao-yang
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  2. Huang Hong-feng
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  3. Sheng-Tu Jian-zhong
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  4. Liu Jian
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Correspondence to Lu Xiao-yang.

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Project (No. 20040462) supported by the Foundation of Education Bureau of Zhejiang Province, China

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Xiao-yang, L., Hong-feng, H., Jian-zhong, ST. et al. Pharmacokinetics of mycophenolic acid in Chinese kidney transplant patients. J. Zheijang Univ.-Sci. B 6, 885–891 (2005). https://doi.org/10.1007/BF02840998

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  • DOI: https://doi.org/10.1007/BF02840998

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