Abstract
To study the fundamental characteristics and biosafety of the compound bone morphogenetic protein (BMP) and rhBMP-2/CPC, and to provide a theoretical basis for the compound biologically active artificial bone made of calcium phosphate cement (CPC) and bone morphogenetic protein, simplex CPC was taken as the control group, and the compound with the blending ratio of 1g CPC to 5mg rhBMP-2 was taken as the experimentation group to determine the setting time, compressive strength, acute toxicological and sub acute toxicological properties. The osteogenic characteristic of compound rhBMP-2/CPC was measured by making animal model of radio discontinuous defect. The setting time of the two groups meets the clinical requirements, and the compressive strength of the solidified body of bone cement increases along with increasing the immersion time. Compound rh-BMP-2/CPC has a favorable osteogenic characteristic for animal model of radio discontinuous defect. The fundamental characteristics of the compound rhBMP-2 phosphate bone cement are basically the same as that of CPC, and also have a favorable biosafety and osteogenesis.
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References
Racquel, Zapanta, Le Geros. Proporties of Osteoconductive Biomaterials: Calcium Phosphate[J].Clin Orthop., 2002, 395:81–98
Kuboki Y, Takita H, Kobayashi D,et al. BMP Induced Osteogenesis on the Surface Hydroxyapatite with Geometrically Feasible and Nonfeasible Structures: Topology of Osteogenesis [J].J. Biomed. Master. Res., 1998,39:190–199
Bermudez. Optimization of A Calcium Orthophosphate Cement Formulation Occuring in the Combination of Mono-calcium Phosphate Monohydrate with Calcium Oxide[J].J. Mater. Sci.: Mater. in Med., 1994;5:67
“ISO”. Biological Evaluation of Dental Materials. TR 7405 (E), 1984
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Honghui, W., Chongyi, S., Tiefeng, S. et al. Preparation, fundamental characteristics and biosafety evalution of compound rhBMP-2/CPC. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 21, 116–119 (2006). https://doi.org/10.1007/BF02840855
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DOI: https://doi.org/10.1007/BF02840855