Abstract
Objective: To investigate muscone’s neuroprotective action and its mechanism in rats with acute cerebral ischemic injury.Methods: Rat focal ischemic model of middle cerebral artery occlusion (MCAO) was established by thread inserting method. TTC staining, RT-PCR and Western blot analysis were used to study the effects of muscone on infracted volume, EAAClmRNA and protein levels.Results: Infarcted volume in the muscone treated group was significantly lower than that in the model control group. Compared with normal group, EAAC1 mRNA level increased in the model control group at 6 and 24 hrs, and protein level increased at 24 hrs after modelling, muscone could reduce the increased expression in model rats.Conclusion: Muscone possesses the action of neuroprotection, its mechanism may be related to reduction of EAAC1 and protein expressions.
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This study was supported by the fund of “Hundred Persons Project” of Shanghai Public Health Bureau (No. 97BR016)
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Hui, L., Hu, C., Yin, G. et al. Effect of muscone on neuronal glutamate transporter EAAC1 expression in rats with acute cerebral ischemia. Chin. J. Integr. Med. 9, 285–288 (2003). https://doi.org/10.1007/BF02838617
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DOI: https://doi.org/10.1007/BF02838617