Abstract
Objective: To observe the blocking effect of Huoxiang Zhengqi liquid HXZQL) on histamine release of basophils.Methods: The study was conducted using HXZQL to neutralize and block IgE and antagonize the effect of IL-3 induced enhancing histamine release of bosaphils. Concentration and percentage of histamine release of bosaphils were tested by the basophil histamine release test.Results: The HXZQL drug-serum had obvious inhibitive effect on degranulation of bosaphils induced by IgE antigen-antibody complex (P < 0. 05) and can successfully weaken the histamine release of basophils stimulated by IL-3. When compared with those in the untreated group, it showedP < 0. 01.Conclusion: HXZQL drug-serum may neutralize and block IgE and has inhibitive effects on degranulation of cells when resensitized by antigens. It can also block allergic response type I by antagonizing the effect of IL-3 induced enhancing histamine release.
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The item is subsidized by Natural Science Fund of Fujian Province (No. C96044)
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Chuan-xing, Y., Ling, Z. Experimental researches on inhibitory effect of Huoxiang Zhengqi liquid on histamine release. Chin. J. Integr. Med. 9, 276–280 (2003). https://doi.org/10.1007/BF02838614
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DOI: https://doi.org/10.1007/BF02838614