Abstract
Objective: To observe the clinical effect of Neiyifang (NYF) in treating endometriosis and to explore its therapeutic mechanism through observing its influence on plasma β-endorphin (β-EP) in different menstrual stages and levels of prostaglandins (PGs) in menstruation.Methods:NYF was administered to 104 patients with endometriosis one dose daily with 3 successive menstrual cycles as one therapeutic course. Peripheral blood β-EP level in follicular, luteal and menstrual stages, as well as PGF2α, PGE2, thromboxane B2 and 6-keto-PGFl α levels in menstrual stage were detected by RIA, and controlled with those in 15 healthy persons.Results: (1) The total effective rate of NYF was 81.3% and it showed significant effect in improving patients’ clinical symptoms and physical signs; (2) In menstrual stage, the levels of β-EP, 6-keto-PGFα/ TXB2 were lower(P <0.05) and levels of PGF2α, PGE2, TXB2 and 6-keto-PGF1α were higher (P< 0. 05) in patients than those in control, and the higher the level of PGE2, the severer the menalgia, (3) NYF could increase levels of β-EP, 6-keto-PGF1α, and reduce levels of PGF2α, PGE2α in menstrual stage of patients (all P<0.05).Conclusion: (1) NYF has good clinical effect in treating endometriosis; (2) Patients’ symptom of menalgia is closely related with the excessive high levels of PGF2α and PGE2, PGI2/TXA2 ratio disturbance, and excessive low level of β-EP; (3) NYF could significantly decrease the PGE2, PGF1α levels, increase the 6-keto-PGF1α/TXB2 ratio and the level of β-EP, so as to alleviate the menalgia in patients with endometriosis.
Similar content being viewed by others
References
Goldman MB, Cramer DW. The epidemiology of endometriosis. Prog Clin Biol Res 1990;323: 15–31.
Strathy JH, MolgaardCA, Coulam CB, et al. Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women. Fertil Steril 1982; 38: 667–672.
Andersch B, Milson I. An epidemiological study of young women with dysmenorrhea. Am J Obstet Gynecol 1982; 144: 655.
Third Academic Conference of Special Committee of Obstetrics and Gynecology, Chinese Association of the Integration of Traditional and Western Medicine. Standard for diagnosis and treatment of endometriosis, pregnant hypertension syndrome and female infertility by integrated traditional Chinese and western medicine (draft). CJIM (Chin) 1991; 11(6): 376.
LI JJ. β-endorphin in field of obstetrics and gynecology. Pract J Obstet & Gynecol 1990;6(3): 155.
Nagamasa M, Chiaki L, Yorito Y, et al. Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis. Fertil Steril 2002; 77(2): 297–302.
Nataraj C, Thomas DW, Tilley SL, et al. Receptors for prostaglandin E2 that regulate cellular immune responses in the mouse. J Clin Invest 2001; 108(8): 1229–1235.
Scandella E, Ying Men, Gillessen S, et al. Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-dirived dendritic cells. Blood 2002; 100 (4): 1354–1361.
Author information
Authors and Affiliations
Corresponding author
Additional information
This item was supported by National Funds of Natural Sciences(No. 30070942)
Rights and permissions
About this article
Cite this article
Chao-qin, Y., Zai-long, C., Yu-huan, L. et al. Study on therapeutic mechanism of Neiyifang in treating endometriosis. Chin. J. Integr. Med. 9, 88–92 (2003). https://doi.org/10.1007/BF02838554
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02838554