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Effect of curcumin on the gene expression of low density lipoprotein receptors

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Abstract

Objective: To investigate the molecular mechanisms and effective target ponits of lipid-lowering drug, Rhizoma Curcumae Longae, and study the effect of curcumin on the expression of low density lipoprotein (LDL) receptors in macrophages in mice.Methods: Macrophages in mice were treated with curcumin, which was purified from the ethanolly extraction of Rhizoma Curcumae Longae for 24 h. The LDL receptors expressed in the macrophages were determined by enzyme-linked immunosorbent assay (ELISA) and assay of Dil labeled LDL uptake by flow cytometer.Results: It was found for the first time that 10 μmol/L-50 μmol/L curcumin could obviously up-regulate the expression of LDL receptor in macrophages in mice, and a dose-effect relationship was demonstrated.Conclusion: One of the lipid-lowering mechanisms of traditional Chinese medicine, Rhizoma Curcumae Longae, was completed by the effect of curcumin through the up-regulation of the expression of LDL receptor.

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Authors and Affiliations

  1. Faculty of Life Science, Zhejiang College of Traditional Chinese Medicine, 310053, Hangzhou

    Fan Chun-lei, Qian Ying, Wo Xing-de, Yan Jin & Gao Li-ping

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  1. Fan Chun-lei
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  2. Qian Ying
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  3. Wo Xing-de
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  4. Yan Jin
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  5. Gao Li-ping
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Correspondence to Fan Chun-lei.

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Chun-lei, F., Ying, Q., Xing-de, W. et al. Effect of curcumin on the gene expression of low density lipoprotein receptors. Chin. J. Integr. Med. 11, 201–204 (2005). https://doi.org/10.1007/BF02836505

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  • DOI: https://doi.org/10.1007/BF02836505

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