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Therapeutic effects of Tongxinluo capsule on patients with acute small cerebral infarction and its influence on SPECT brain perfusion image

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Abstract

Objective: To investigate the influence of Tongxinluo capsule (TXL) on regional cerebral blood flow (rCBF) with 99mTc-ECD single photon emission computed tomography (SPECT) brain perfusion imaging, and to observe the therapeutic effects of TXL on acute small cerebral infarction (ASCI).Methods: Thirty-four patients with ASCI were enrolled and randomly divided into two groups: the control group (n = 17) was treated with the conventional treatment, i.e. 1. 0g of Citicoline added into 300 ml normal saline for intravenous dripping daily for 2 weeks and 0.8 g of Piracetam taken three times a day orally for 4 weeks, and the treatment group (n = 17) was treated additionally with 4 TXL capsules three times a day for 4 weeks besides the conventional treatment. The 99mTc-ECD SPECT brain perfusion imaging was performed before and after treatment to observe the change of rCBF, and the neurological deficit was evaluated by Edinburgh-Scandinavia stroke scale (SSS) scores and Barthel index (BI) at the same time.Results: After treatment, the rCBF in the treatment group was significantly improved (P<0.01), while that in the control group remained unchanged, with the comparison of the rCBF in the two groups after treatment showing significant difference (P<0.01). In addition, the SSS score was significantly lower and Bl significantly higher in the treatment group than those in the control group respectively after treatment.Conclusion: TXL could effectively improve rCBF and lessen the neurological deficit symptoms in patients with ASCI.

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Authors and Affiliations

  1. Neurological Department of Qilu Hospital, Shandong University, 250012, Jinan

    Zhou Sheng-nian & Zhou Guo-yu

  2. Western Medicine Department, Shandong University of Traditional Chinese Medicine, China

    Liu Li-qing

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  1. Zhou Sheng-nian
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  2. Zhou Guo-yu
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  3. Liu Li-qing
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Correspondence to Zhou Sheng-nian.

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Sheng-nian, Z., Guo-yu, Z. & Li-qing, L. Therapeutic effects of Tongxinluo capsule on patients with acute small cerebral infarction and its influence on SPECT brain perfusion image. Chin. J. Integr. Med. 10, 107–111 (2004). https://doi.org/10.1007/BF02836378

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  • DOI: https://doi.org/10.1007/BF02836378

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