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Congenital Hypothyroidism

  • Symposium: Pediatric Endocrinology-II
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Availability of sensitive radioimunoassays for T4 and TSH has simplified the detection and treatment of congenital hypothyroidism. Early diagnosis by newborn screening and prompt treatment should minimize the serious complications of mental retardation. Absence of clear cut signs and symptoms early in the life requires laboratory testing for early diagnosis. The high cost effectiveness of the screening programme has resulted in the implementation of mass screening in many countries. Several studies indicate a favourable IQ with initiation of treatment before the age of 3 months. Neonatal laboratory screening programs have made it possible to initiate treatment before one month of age. This may further improve the outcome of this common cause of preventable mental retardation.

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Abbreviations

CH:

Congenital hypothyroidism

T4 :

Thyroxine

T3 :

Tri iodothyronine

rT3 :

Reverse T3

TSH:

Thyrotropin

TLH:

Thyrotropln releasing hormone

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Authors and Affiliations

  1. Department of Pediatrics, Rush Medical School, Chicago, USA

    M. S. Laxmi Narayan M.D., F.A.A.P.

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  1. M. S. Laxmi Narayan M.D., F.A.A.P.
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Narayan, M.S.L. Congenital Hypothyroidism. Indian J Pediatr 49, 621–628 (1982). https://doi.org/10.1007/BF02834570

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