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Immune status of children and responses to DPT vaccination against Diphtheria as judged by schick test and indirect hemagglutination test

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Abstract

Immune status of 172 children aged between 6 months and two years was studied, using Schick and indirect hemagglutination test (IHA). Schick test was done in all and IHA in 84 of them. Schick negativity rate was found to be 84.3 percent, whereas IHA test showed protective titers in 55.9 percent of subjects. Immunity to diphtheria by IHA could be confirmed only in 68 percent of schick negative children. Response to even a single dose of DPT was significant (p< 0.01) in comparison to unimmunized children. There was no difference in two dose and three dose schedules (75 percent and 80 percent of subjects, had protective titers respectively), of primary immunization against diphtheria as judged by IHA test. Primary immunization followed by a booster provided 100 Percent protection in recently immunized children as judged by IHA test.

It is recommended that Schick test along with IHA should be used to study the immunity to diphtheria.

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Authors and Affiliations

  1. Departments of Pediatrics and Medical Microbiology, Postgraduate institute of Medical Education & Research, Chandigarh

    A. Rastogi M.D., L. Kumar M.D. (Associate Professor), A. Ayyagari M.D., V. Kumar M.D. & V. Dhar M.D.

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  1. A. Rastogi M.D.
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  2. L. Kumar M.D.
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  3. A. Ayyagari M.D.
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  4. V. Kumar M.D.
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  5. V. Dhar M.D.
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This is a part of Study Supported by ICMR Scheme No. 3/1/2/79 (232)/38-RB

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Rastogi, A., Kumar, L., Ayyagari, A. et al. Immune status of children and responses to DPT vaccination against Diphtheria as judged by schick test and indirect hemagglutination test. Indian J Pediatr 49, 501–506 (1982). https://doi.org/10.1007/BF02834554

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