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Hepatic cell apoptosis was triggerred by HBx accumulation and independent on verapamil

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Summary

In order to study the roles of HBx and calcium inhibitor verapamil in apoptosis of human normal hepatic cells, L02-off, a pTet-off stably integrated human hepatic cell line was established, in which HBx expression was tightly induced by Doxycycline. The effect of different amounts of HBx and verapamil on apoptosis of human normal hepatic cells was detected. The study showed that apoptosis was triggered by accumulation of intracellular HBx, while verapamil had no effects on the apoptotic process. It was concluded that apoptosis mediated by HBx was dose-dependent but calcium-independent.

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Authors and Affiliations

  1. Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China

    Wang Haiping, Chen Xiaoping & Bai Xiangjun

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  1. Wang Haiping
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  2. Chen Xiaoping
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  3. Bai Xiangjun
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WANG Haiping, male, born in 1972, Doctor in Charge

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Haiping, W., Xiaoping, C. & Xiangjun, B. Hepatic cell apoptosis was triggerred by HBx accumulation and independent on verapamil. Current Medical Science 24, 281–283 (2004). https://doi.org/10.1007/BF02832013

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  • DOI: https://doi.org/10.1007/BF02832013

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