Summary
The expression of transforming growth factor-β1 (TGF-β1) in placental tissue of pregnancy-induced hypertension (PIH) and the relationship between the level of expression of TGF-β1 and the amount of vascular cell adhesion molecule-1 (VCAM-1) in serum was studied. Immunohistochemistry ABC was used to detect the expression and distribution of TGF-β1 in placental tissues in 40 PIH women and 20 normal pregnancy women. High resolution pathological image analysis system was used to determine the quality of TGF-β. The VCAM-1 in serum was examined by enzyme linked immunoabsorbent assay (ELISA). The results showed that TGF-β1 could be express in syncytiotrophoblast. The levels of TGF-β1 expression in placental tissues of the patients with moderate and severe PIH were significantly higher (P<0.05), while the serum VCAM-1 was significantly lower than in normal group (P<0.01). There was a significant positive correlation between the expression of the TGF-β1 in placental tissues and the serum VCAM-1 (r=0.969,P<0.01). It was concluded that the level of TGF-β1 expressin in PIH was increased and was positively correlated with the amount of serum VCAM-1, indicating that they might be involved in the pathogenesis of PIH.
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References
Roberts J M, Redman C W. Pre-eclampsia: more than pregnancy-induced hypertension. Lancent, 1993, 341:1447
Le J. Obstetrics and Gynecology. Beijing: People's Health Press, 2002. 114
Dungy L J, Siddiqi T A, Sohaib K. Transforming growth factor-β1 expression during placental development. Am J Obstet Gyneacol, 1991, 165:853
Del Gobbo V, Giganti M G, Zenobi R. The immunosuppressive cytokines influence the fetal survival in patients with pregnancy-induced hypertension. Am J Reprod Immunol, 2000, 44:214
Lynsey L, Eleeanor J, Judith Aet al. Immunoregulatory molecules during pregnancy and at birth. J Repro Immuno, 2002, 56:19
Zhou Y, Damsky C H, Fisher S J. Preeclampsia is associated with failure of human cytotrophoblasts to mimmmic a vascular adhesion phenotype. J Clin Invest, 1997, 99:2152
Chen H P, Ma T Y, Zhang L F. The pathological changes of placental and umbilical vessels in pregnancy induced hypertension. Tongji Yi Ke Da Xue Xue Bao (Chinese), 1996, 25:412
Fortunato S J, Menon R, Lonbardi S J. Interleukin-10 and transforming growth factor-beta inhibit amniochorion tumor necrosis factor-alpha production by contrasting mechanisms of action: Therapeutic implications in prematurity. Am J Obstet Gynecol, 1997, 177:803
Park S K, Yang W S, Lee S Ket al. TGF-beta(1) down-regulates inflammatory cytokine-induced VCAM-1 expression in cultured human glomerular endothelial cells. Nephrol Dial Transplant, 2000, 15:596
Gamble J R, Bradley S, Noack Let al. TGF-beta and endothelial cells inhibit VCAM-1 expression on human vascular smooth muscle cells. Arteioscler Thromb Vasc Biol, 1995, 15:949
Kienzle G, von kempis J. Vascular cell adhesion molecule 1 (CD106) on primary articular chondrocytes: functional regulation of expression by cytokines and comparison with the intracellular adhesion molecule 1 (CD54) and very late antigen 2. Arthritis Rheum, 1998, 41:1296
Blobe G C, Schiemann W P, Lodsih H F. Role of transforming growth factor β in human disease. J N Engl J Med, 2000, 342:1350
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XIANG Wenpei, female, born in 1974, Doctorial Candidate
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Wenpei, X., Xiaoyan, X. & Hanping, C. Expression of TGF-β1 in placenta of the patients with pregnancy-induced hypertension and its relationship with serum VCAM-1. Current Medical Science 25, 82–84 (2005). https://doi.org/10.1007/BF02831394
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DOI: https://doi.org/10.1007/BF02831394