Summary
The expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) in human meningiomas and the relationships between their expression and the tumors' histological features and angiogenesis were investigated by means of immunohistochemical technique. The expression of bFGF and FGFR-1 was detected by antibody of bFGF or FGFR-1. the tumors' angiogenesis was evaluated by microvascular density (MVD) and, which was observed by use of CD34-antibody immunohistochemically. The results showed that there were varied degrees of the expression of bFGF and FGFR-1 proteins in meningiomas. The expression was correlated with the tumors' histological characters and angiogenesis. It was concluded that bFGF and FGFR-1 might play important roles in meningiomas' angiogenesis and proliferation. The expression positive rate of bFGF and FGFR-1 may provide an indication of evaluating the histological and malignant degree of the tumor.
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YI Wei, male, born in 1973, M. D., Ph. D.
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Wei, Y., Jian, C., Golwa, F.H. et al. Basic fibroblast growth factor and fibroblast growth factor receptor-1 in human meningiomas. Current Medical Science 25, 75–77 (2005). https://doi.org/10.1007/BF02831392
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DOI: https://doi.org/10.1007/BF02831392