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Effect of calcium dobesilate on nephropathy in type 2 diabetic rats

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Summary

In order to investigate the effects and mechanisms of calcium dobesilate on renal lesions in experimental type 2 diabetic rats, dibetic rats were randomly divided into control group (group C) and experimental group (group D) treated with calcium dobesitate. The serum creatinine (Scr), protein kinase C (PKC), creatinine clearance (Ccr), transforming growth factor-beta1 (TGF-β1), type IV collagen were compared among the groups after 24 weeks. The renal tissues were observed under light microscopy and electron microscopy. The results showed that after 24 weeks, Scr, PKC, TGF-β1 in group D were significantly lower than in group C, meanwhile, renal pathologic changes in group D were improved. Ccr had no difference between group C and group D. It was concluded that calcium dobesilate could ameliorate renal lesions in diabetic rats through inhibiting PKC and TGF-β1

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Authors and Affiliations

  1. Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China

    Liu Xiaocheng & Liu Xinming

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  1. Liu Xiaocheng
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  2. Liu Xinming
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LIU Xiaocheng, female, born in 1946, Professor

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Xiaocheng, L., Xinming, L. Effect of calcium dobesilate on nephropathy in type 2 diabetic rats. Current Medical Science 25, 36–38 (2005). https://doi.org/10.1007/BF02831381

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  • DOI: https://doi.org/10.1007/BF02831381

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