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The use of chlorpropamide in diabetes insipidus in children

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Abstract

Three children with idiopathic partial central diabetes insipidus were treated with chlorpropamide. All responded to therapy satisfactorily. No untoward side effects were noted. On follow up, their urinary volumes and osmolalities were normal. The mechanism of action, dosage and side effects of chlorpropamide are reviewed.

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References

  1. Pepys J, Jenkins PA, Lachman PJ, An iatrogenic autoantibody. Immunological responss to ‘pitutory snuff’ in patients with diabetes insipidus. J. Endocrinol; 33: 8 1965

    Google Scholar 

  2. Dorothy JB, Thomas PF Jr. l-Deamino-8- D-arginine vasopressin in the treatment of central diabetes insipidus in childhood J. Pediatr 92: 1011, 1978

    Article  Google Scholar 

  3. Vallet HL, Prasad M, Richard B Goldbloom. Chlorpropamide treatment of diabetes insipidus in children Pediatrics 45: 246, 1970

    PubMed  CAS  Google Scholar 

  4. Arduino F, Ferraz FPJ, Rodrigues J Antidiuretic action of chlorpropamide in indiopathic diabetes insipidus J Clin Endocrinol 26: 1325, 1966

    CAS  Google Scholar 

  5. Ehilich KM, Kooh SW. Oral chlorpropamide in diabetes insipidus. Lancet, 1: 890, 1969

    Article  Google Scholar 

  6. Hocken AG, Longson D. Reduction of free water clearance by chlorpropamide. BMJ 1: 355, 1969

    Article  Google Scholar 

  7. Kunstadter RN, Cabana FC, Oh W. Treatment of vasopressin sensitive diabetes insipidus with chlorpropamide. Amer J Dis Child 117:436, 1969

    PubMed  CAS  Google Scholar 

  8. Lambett AE, Jeanrenaud B, Renald AE. Enhancement of caffein of glucagon induced and tolubtamide induced insulin release from isolated fetal pancreatic tissue. Lancet 1: 819, 1967

    Article  Google Scholar 

  9. Miller M, Moses AM. Potentiation of vasoprrssin action by chlorpropamide, in vitro. Endocrinology 86: 1024, 1970

    PubMed  CAS  Google Scholar 

  10. Ingelfinger JR, Hays RM. Evidence that chlorpropamide and vasopressin share a common site of action. J Clin Endocrinol 29:738,1969

    CAS  Google Scholar 

  11. Loxada ES, Gouau J, Frankin N.Apple GB and Hays RM. Studies of the mode of action of sulphonylureas and phenylacetamide in enhancing the effect of vasopressin. J Clin Eddocrinol 34: 764, 1972

    Google Scholar 

  12. Ettinger B, Forsham PH. Mechanism of chlorpropamide antidiuresis in diabetes insipidus J Clin Endocrinol 31: 552, 1970

    Article  CAS  Google Scholar 

  13. Moses AM, Numann P, and Miller M. Mechanism of chlorpropamide induced antidiuresis in man. Evidence for release of ADH and enhancement of peripheral action. Metabolism 59: 66, 1973

    Google Scholar 

  14. Guillmin R. Beta lipoprotein and Endorphin implications of current knowledge Hosp Practice 53: 60, 1978

    Google Scholar 

  15. Robert M Ehrlich, Sang Whay Kooh. The use of chlorpropamide in diabetes insipidus in children Pediatrics 45: 236, 1970

    PubMed  CAS  Google Scholar 

  16. New and nonofficial drugs, Philadelphia and Montreal: JB Lippincott company 1963, p 721

  17. Linshaw MA, Sey M, Di George AM. Grushin AB A potential danger of oral chlorpropamide therapy, Impared excretion of water load J Clin Endocrinol 34: 562, 1972

    CAS  Google Scholar 

  18. Goodman AD, Carter RD. A study of the mechanism of the action chlorothiazide in diabetes insipidus Metabolism. 34: 562 1972

    Google Scholar 

  19. Havard CWH, Wood PHN. The effect of chlorothiazide on renal water excretion in diabetes insiyidus. Clin Sci 21: 321 1961

    PubMed  CAS  Google Scholar 

  20. Francois Bonnici Antidiuretic effect of clofiorate and carbamazepine in Diabetes Insipidus. Studies on free water clearance and response to water load Clinical Endocrinol 2: 265, 1973

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Authors and Affiliations

  1. Department of Pediatrics, Postgraduate Institute of Medical Education & Research Chandigarh, India

    Vikram Kumar M.D. & Lata Kumar M.D. (Associate Professor)

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  1. Vikram Kumar M.D.
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  2. Lata Kumar M.D.
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Kumar, V., Kumar, L. The use of chlorpropamide in diabetes insipidus in children. Indian J Pediatr 49, 281–286 (1982). https://doi.org/10.1007/BF02830769

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  • DOI: https://doi.org/10.1007/BF02830769

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