Skip to main content
SpringerLink
Log in

Effect of autonomic nervous system on the transmural dispersion of ventricular repolarization in intact canine

  • Published:
Current Medical Science Aims and scope Submit manuscript

Summary

The effect of the autonomic nerves on the transmural dispersion of ventricular repolarization in intact canine was investigated. By using the monophasic action potential (MAP) recording technique, monophasic action potentials (MAPs) of the epicardium (Epi), midmyocardium (Mid) and endocardium (Endo) were recorded simultaneously by specially designed plunge-needle electrodes at the left ventricular free wall in 12 open-chest dogs. MAPD90 and transmural dispersion of repolarization among three myocardial layers as well as the incidence of the EAD before autonomic that the MAPD90 of Epi, Mid and Endo before autonomic nervous stimulation were 278±11 ms, 316±16 ms and 270±12 ms respectively, the MAPD90 of Mid was significantly longer than that of Epi or Endo (P<0.01). MAPD90 of Epi, Mid and Endo were shortened by 19±4 ms, 45±6 ms, 18±3 ms respectively during sympathetic stimulation. Compared with that of the control, the transmural dispersion of repolarization during sympathetic stimulation was shortened from 44±4 ms to 15±3 ms (P<0.01), but early afterdepolarizations were elicited in the Mid of 5 dogs (41%) during sympathetic stimulation. Parasympathetic stimulation did not significantly affect the MAPD90 in the three layers. It is concluded that there is the transmural dispersion of ventricular repolarization in intact canine. Sympathetic stimulation can reduce transmural dispersion of repolarization, but it can produce early afterdepolarizations in the Mid. Parasympathetic stimulation does not significantly affect the transmural dispersion of ventricular repolarization.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Sicouri S, Antzelevitch C. A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle: the M cells. Circ Res, 1991, 68: 1279

    Article  Google Scholar 

  2. Liu S W, Lin Z H. The relationship between the autonomic nerves and arrhythmia. Chin J Cardiol (Chinese), 1999, 27(1):75

    CAS  Google Scholar 

  3. Li Y T, Zhang C T, Lu Z Y. Experimental observation on genesis of U wave in ECG in rabbits. Chin J Cardiol (Chinese), 2000, 28(2):124

    Google Scholar 

  4. Antzelevitch C, Sicouri S, Litovsky S Het al. Heterogeneity with the ventricular wall: electrophysiology and pharmacology of epicardial, endocardial and M cells. Circ Res, 1991, 69:1427

    Article  CAS  PubMed  Google Scholar 

  5. Zipes D P. Influence of myocardial ischemia and infarction on autonomic innervation of heart. Circulation, 1990, 82(4):1095

    Article  CAS  PubMed  Google Scholar 

  6. Burashnikov A, Antzelevitch C. Differences in the electrophysiologic response of four canine ventricular cell types to alpha1-adrenergic agonists. Cardiovasc Res, 1999, 43(4):901

    Article  CAS  PubMed  Google Scholar 

  7. Shimizu W, Antzelevitch C. Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: Effect of β-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and Torsade de Pointes. Circulation, 1998, 98:2314

    Article  CAS  PubMed  Google Scholar 

  8. Shimizu W, Antzelevitch C. Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of long QT syndrome. JACC, 2000, 35:778

    Article  CAS  PubMed  Google Scholar 

  9. Takei M, Sasaki Y, Yonezawa Tet al. The autonomic control of transmural dispersion of ventricular repolarization in anesthetized dog. J Cardiovasc Eletrophysiol, 1999, 10(8):124

    Google Scholar 

  10. Priori S G, Mantica M, Schwartz P J. Delayed afterdepolarizations elicited in vive by left stellate ganglion stimulation. Circulation, 1988, 78:178

    Article  CAS  PubMed  Google Scholar 

  11. Antzelevith C, Sicouri S. Clinical relevance of cardiac arrhythmia generated by afterdepolarizations: The role of M cells in the generation of U waves, triggered activity and torsade de pointes. JACC 1994, 23:259

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan

    Zhang Cuntai, Xu Dawen, Li Yang, Liu Nian, Wang Lin & Lu Zaiying

Authors
  1. Zhang Cuntai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xu Dawen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Li Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Liu Nian
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Wang Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Lu Zaiying
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Zhang Cantai, male, born in 1963, Associate Professor

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cuntai, Z., Dawen, X., Yang, L. et al. Effect of autonomic nervous system on the transmural dispersion of ventricular repolarization in intact canine. Current Medical Science 24, 37–40 (2004). https://doi.org/10.1007/BF02830701

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02830701

Key words

Search

Navigation