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Study for interrelationship between human herpes simplex virus type 2 and leukemia

  • Published:
Wuhan University Journal of Natural Sciences

Abstract

Two different strains of human herpes simplex virus type 2 (HHSV-2) and /or murine leukemia virus (MLV) were inoculated into newborn mice. In mice of mixed infection with MLV plus HHSV-2(333) or MLV plus HHSV-2(Wu)incidences of leukemia were respectively 79.16% and 75.00%,and in those inoculated with MLV alone were 41.02% and 44.74% in the experiment for 3 months. The differences of incidences between the two conditions were highly significant (p<0.01). On the contrary, no leukemia was detected in mice that were inoculated with HHSV-2 (333) or HHSV-2 (Wu) alone and in controls. Leukemia developing time of mice infected with two viruses was earlier than with MLV alone. It is obvious that the induction of murine leukemia resulted from infection of MLV and was independent of HHSV-2 (333) and HHSV-2(Wu). Both risen incidences and shortened latencies of murine leukemia were in close relationship with infection of HHSV-2(333) and HHSV-2(Wu).

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References

  1. Peters W P, Kufe D, Schlom J,et al. Biological and Biochemical Evidence for an Interaction Between Marek's Disease Herpesvirus and Avian Leukosis Virusin Vivo.Proc Natl Acad Sci, 1973,70:3175.

    Article  Google Scholar 

  2. Frankel J W, Farrow W M, Prickett C O,et al. Responses of Isolator-derived and Conventional Chickens to Marek's Disease Herpesvirus and Avian Leukosis Virus.J Natl Cancer Inst, 1974,52:1491.

    Google Scholar 

  3. Flugel R M, Darai G, Braun R,et al. Activation of an Endogenous C-type RNA Virus in Rat Embryo Cells after Transformation by Herpes Simplex Virus 1 and 2.J Gen Virol, 1997,36:365.

    Google Scholar 

  4. Shang S Z, Biologic Properties of Herpes Simplex Virus type 2 Irradiated by Ultraviolet Light.Acta Microbiol sinica, 1983,23:373.

    Google Scholar 

  5. Rapp F, Turner N, Biochemical Transformation of Mouse Cell by Herpes Simplex Virus Type 1 and 2: Comparison of Different Methods for Inactivation of Viruses.Arch Virol, 1978,56:77.

    Article  Google Scholar 

  6. Zhemg B F, Chen L, Shan Y F, Isolation and Characterization of the Mouse Leukemia Virus: I. Isolation of the Mouse L 6565 Lymphoctyic Leukemia Virus.Acta Acad Med Prim Shanghi, 1981,8:1.

    Google Scholar 

  7. Zheng B F, Chen L, Shan Y F, Isolation and Characterization of the Mouse Leukemia Virus: II. Detection of Reverse Transcriptase Activity of the Mouse L 6565 Lymphocytic Leukemia Virus.Acta Acad Med Prim Shanghi, 1981,8:10.

    Google Scholar 

  8. Bundy L M, Ru M, Zheng B F,et al. Biological Characterization and Molecular Cloning of Murine C-type Retroviruses Derived from the TSZ Complex from Mainland China.Virol, 1995,212: 367.

    Article  Google Scholar 

  9. Yamamoto N, Hinuma Y, Viral Etiology of Adult T Cell Leukemia.J Gen Virol, 1985,66:1641.

    Article  Google Scholar 

  10. Hampar B, Aaronson S A, Derge J G,et al. Activation of an Endogenous Mouse Type C Virus by Ultraviolet-irradiated Herpes Simplex Virus Type 1 and 2.Proc Natl Acad Sci. 1976,73:646.

    Article  Google Scholar 

  11. Hsiung G D, McTighe A H, An Animal Model for DNA-RNA Virus Interaction Based Upon Virological and Histological Findings.Cancer Res, 1976,36:674.

    Google Scholar 

  12. LIU J J, Chen M H, Chang W Y. A Preliminary Observation on Synergistic Induction of Lymphocytic Leukemia by Herpes Simplex Virus Type 2 with Leukemia Virus in Mice.Acta Acad Med Hubei, 1985,1:16.

    Google Scholar 

  13. Galloway D A, McDougall J K, Alteration in the Cellular Phenotype Induced by Herpes Simplex Viruses.J Med Virol, 1990,31:36.

    Article  Google Scholar 

  14. Tumas-Brundage K M, Garret W, Blank K,et al. Murine Leukemia Virus Infects Early Born Marrow Progenitors in Immunocompetent Mice.Virol, 1996,224:573.

    Article  Google Scholar 

  15. Yin L H, Zheng S G, Cheng L,et al. Preliminary Study on Oncogene Expression of L 6565 Mice Leukemia.Chin J Pathophysiol, 1997,13:173.

    Google Scholar 

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Authors and Affiliations

  1. Virus Research Institute, Hubei Medical University, 430071, Wuhan, China

    Liu Jian-jun & Yang zhan-qiu

  2. Department of Pathology, Second Affiliated Hospital, Hubei Medical University, 430071, Wuhan, China

    Guo Guang-song

  3. First Affiliated Hospital, Hubei Medical University, 430071, Wuhan, China

    Xu Shun-xian

Authors
  1. Liu Jian-jun
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  2. Guo Guang-song
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  3. Xu Shun-xian
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  4. Yang zhan-qiu
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Additional information

Foundation item: Supported by the National Natural Science Foundation of China (No. 59678017)

Biography: Liu Jian-jun (1954-), male, associate research fellow, research direction: experimental oncology.

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Jian-jun, L., Guang-song, G., Shun-xian, X. et al. Study for interrelationship between human herpes simplex virus type 2 and leukemia. Wuhan Univ. J. Nat. Sci. 5, 366–372 (2000). https://doi.org/10.1007/BF02830158

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  • DOI: https://doi.org/10.1007/BF02830158

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