Skip to main content
SpringerLink
Log in

Expression of CD40 and CD40L on peripheral blood monoculear cells in patients with condyloma acuminatum

  • Published:
Journal of Huazhong University of Science and Technology [Medical Sciences] Aims and scope Submit manuscript

Summary

To observe the expression of CD40/CD40L on peripheral blood mononuclear cells (PBMC) in patients with condyloma acuminatum (CA), flow cytometry was employed to examine the expression of CD40 and CD40L on PMBC in 36 patients with CA and 20 healthy controls. Our results showed that mean level of CD40 expression in CA patients was significantly lower than that in the controls (6.58%±2.74% vs 14.81%±6.12%,t=5.703,P<0.05); the average level of CD40L in CA patients was also significantly lower than that in the controls (0.73%±0.54% vs 2.67±2.43%,t=3.532,P<0.05). Our results suggest that the reduced costimulatory interaction of CD40 and CD40L in CA patients may be one of the important factors responsible for the low cellular immunity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Frazer I H. The role of the immune system in anogenital human papillomavirus. Australas J Dermatol, 1998, 39 (Suppl 1): S5–7

    Google Scholar 

  2. Zarcone R, Bellini P, Cardone Get al. Vulvo-vaginal HPV infection, immunological aspects. Minerva Ginecol, 1996, 48(3): 61–3

    PubMed  CAS  Google Scholar 

  3. Matorras R, Ariceta J M, Rementeria Aet al. Human immunodeficiency virus-induced immunosuppression: a risk factor for human papillomavirus infection. Am J Obstet Gynecol, 1991, 164(1): 42–4

    PubMed  CAS  Google Scholar 

  4. Frazer I H. Immunology of papillomavirus infection. Curr Opin Immunol, 1996, 8(4): 484–91

    Article  PubMed  CAS  Google Scholar 

  5. Frazer I H, Thomas R, Zhou Jet al. Potential strategies utilised by papillomavirus to evade host immunity. Immunol Rev, 1999, 168: 131–132

    Article  PubMed  CAS  Google Scholar 

  6. Diehl L, Den Boer A T, van der Voort E Iet al. The role of CD40 in peripheral T cell tolerance and immunity. J Mol Med, 2000, 8(7): 363–71

    Article  Google Scholar 

  7. Sun Y, Peng D, Lecanda Jet al. In vivo gene transfer of CD40 ligand into colon cancer cells induces local production of cytokines and chemokines, tumor eradication and protective antitumor immunity. Gene Ther, 2000, 7(17): 1467–76

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Tongji Hospital Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China

    Liu Dongxian, Jiang Wen, Chen Xingping & Chen Yingling

  2. Division of clinical Immunology, Tongji Hospital Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China

    Yang Dongliang

Authors
  1. Liu Dongxian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jiang Wen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chen Xingping
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chen Yingling
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yang Dongliang
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

LIU Dongxian, female, born in 1962, Associate Professor

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dongxian, L., Wen, J., Xingping, C. et al. Expression of CD40 and CD40L on peripheral blood monoculear cells in patients with condyloma acuminatum. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 26, 378–379 (2006). https://doi.org/10.1007/BF02829582

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02829582

Key words

Search

Navigation