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Different effects of capsaicin on IA and IK in pain-conduct neurons of rats

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Summary

The different effects of capsaicin on IA and IK currents in pain-conduct neurons of trigeminal ganglia (TG) were investigated. In cultured TG neurons of rats, whole-cell patch clamp techniques were used to record the IA and IK before and after capsaicin perfused. Results revealed that 1 μmol/L capsaicin could inhibit the amplitude of IA by 48.2% (n=10,P<0.05), but had no inhibitory effect on IK (n=7,P>0.05). Ten μmol/L capsaicin could significantly inhibit the amplitude of IA by 93.2% (n=8,P<0.01), but only slightly inhibit the amplitude of IK by 13.2% (n=7,P<0.05). Neither 1 μmol/L nor 10 μmol/L capsaicin had effects on the active curve of IA and IK. It was concluded that capsaicin could selectively inhibit the IA current, and this effect might involve in the analgesic mechanisms of capsaicin.

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Authors and Affiliations

  1. Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China

    Fu Hui, Liu Hui, Cao Xuehong, Hu Yan, Xiang Jizhou & Liu Lieju

Authors
  1. Fu Hui
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  2. Liu Hui
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  3. Cao Xuehong
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  4. Hu Yan
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  5. Xiang Jizhou
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  6. Liu Lieju
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Additional information

FU Hui, female, born in 1977, Lecturer

This project was supported by a grant from the National Natural Sciences Foundation of China (No. 30271500).

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Hui, F., Hui, L., Xuehong, C. et al. Different effects of capsaicin on IA and IK in pain-conduct neurons of rats. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 26, 275–277 (2006). https://doi.org/10.1007/BF02829549

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  • DOI: https://doi.org/10.1007/BF02829549

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