Skip to main content
SpringerLink
Log in

Detection of serum hyaluronic acid and laminin in patients with bladder tumors

  • Published:
Current Medical Science Aims and scope Submit manuscript

Summary

In order to investigate the changes of serum hyaluronic acid (HA) and laminin (LN) levels and their clinical implication in the patients with bladder tumors, the serum HA and LN levels in 34 patients with bladder tumor and 30 cases of control group were detected by radioimmunoassay before and after operation. The results showed that the serum HA and LN levels in the patients with bladder tumors were significantly higher than those in control group (P<0.01) before operation, and decreased significantly after operation (P<0.05). The serum levels of HA and LN in infiltration tumors were higher than those in superficial tumors (P<0.05). The serum HA and LN levels in patients with lymph node metastasis were higher than those without lymph node metastasis (P<0.01). The investigation revealed that HA and LN might be involved in the malignant biology behavior of bladder tumors and could be used as important markers of assistant diagnosis and condition monitoring.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Pellegrini R, Martignone S, Tageliabue Eet al. Prognostic significance of laminin production in relation with its receptor expression in human breast carcinomas. Breast Cancer Res Treat, 1995, 35: 195

    Article  CAS  PubMed  Google Scholar 

  2. Liotta L A. Tumor invasion and metastasis-role of the extra cellular matrix: roads memorioal award lecture. Cancer Res, 1986, 46: 1

    CAS  PubMed  Google Scholar 

  3. Manley G, Christine W. Serum hyaluronic acid in patients with disseminated neoplasm. J Clin Pathol, 1997, 40: 626

    Article  Google Scholar 

  4. Skubitz A P, Bast R C Jr, Wayner E Aet al. Expression of alpha 6 and beta 4 integrins in serous ovarian carcinoma correlates with expression of the basement membrane protein laminin. Am J Pathol, 1996, 148(5): 1445

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Iwahashi M, Ikoma M, Otani Tet al. Increased serum concentration of type IV collagen and laminin associated with granulosa cell tumor of the ovary. J Clin Pathol, 1997, 50(1): 77

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, The First Hospital, Medical College of Shihezi University, 832008, Xinjiang

    Li Lingxun & Ding Guofu

Authors
  1. Li Lingxun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ding Guofu
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Li Lingxun, male, born in 1969, Doctor in Charge

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lingxun, L., Guofu, D. Detection of serum hyaluronic acid and laminin in patients with bladder tumors. Current Medical Science 23, 42–43 (2003). https://doi.org/10.1007/BF02829459

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02829459

Key words

Search

Navigation