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The effect of paroxetine on depressive symptom with somatic disease and change of platelet 5-HT concentration

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Summary

To study the effect of paroxetine on depressive symptom accompanying somatic disease and the value of platelet 5-HT concentration in the diagnosis of depression, 30 patients with depressive symptom were treated with paroxetine. All patients were evaluated on Zung and HAMD scale and assayed of platelet 5-HT concentration before and after treatment. It was found that patients had a lower level of platelet 5-HT concentration than healthy people (P<0.01). After six weeks of treatment, depressive and somatic symptoms were both improved (P<0.01) and platelet 5-HT concentration was even lower (P>0.05). It was suggested that paroxetine was a good antidepressant and platelet 5-HT concentration was useful in the screening of depression.

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Authors and Affiliations

  1. Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430000, Wuhan

    Zheng Kai & Shi Tinghui

  2. Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430000, Wuhan

    Liu Xiaoqing

Authors
  1. Zheng Kai
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  2. Shi Tinghui
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  3. Liu Xiaoqing
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Zheng Kai, female, born in 1974, Resident

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Kai, Z., Tinghui, S. & Xiaoqing, L. The effect of paroxetine on depressive symptom with somatic disease and change of platelet 5-HT concentration. Current Medical Science 23, 29–31 (2003). https://doi.org/10.1007/BF02829455

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  • DOI: https://doi.org/10.1007/BF02829455

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