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Effects of heparin on transforming growth factor-β1 and extracellular matrix components in the glomeruli of diabetic rats

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Summary

The effects of heparin on the expression of transforming growth factor-β1 (TGF-β1) and two extracellular matrix components laminin (LN) and fibronectin (FN) in diabetic rat glomeruli were investigated. Twenty-six rats were randomly divided into control group (C,n=8), diabetic group (D,n=9), and diabetes+heparin group (DH,n=9). After 8-week therapy of heparin (200 U once daily by abdominal injection), TGF-β1, LN and FN expression in glomeruli was detected by immunohistochemical method. The results showed that the expression levels of TGF-β1, LN and FN were higher in group D than in group C. It was found that heparin could reduce 24-h urinary albumin excretion and inhibit overexpression of TGF-β1, LN and FN in glomeruli of diabetic rats. It suggested that the inhibitory effect of heparin on diabetic glomerular sclerosis was at least partly related with the inhibition of TGF-β1 expression.

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Authors and Affiliations

  1. Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan

    Li Yuanhong, Peng Lixun, Zhang Muxun, Ouyang Jinzhi & Zhang Jianhua

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  1. Li Yuanhong
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  2. Peng Lixun
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  3. Zhang Muxun
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  4. Ouyang Jinzhi
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  5. Zhang Jianhua
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LI Yuanhong, female, born in 1973, Resident

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Yuanhong, L., Lixun, P., Muxun, Z. et al. Effects of heparin on transforming growth factor-β1 and extracellular matrix components in the glomeruli of diabetic rats. Current Medical Science 23, 10–12 (2003). https://doi.org/10.1007/BF02829449

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  • DOI: https://doi.org/10.1007/BF02829449

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