Summary
This experiment aimed to investigate the effect of adrenergic system in the subnucleus commissuriu of nucleus solitrius tractus (CNTS) on renal nerve discharges. Norepinephrine (NE) was microinjected into the CNTS of rabbits and mean arterial blood pressure (MAP) and renal nerve discharges (FRND) were synchronously recorded. The results indicated that (1) microinjection of norepinephine into the CNTS of rabbit could significantly attenuate the frequency of renal nerve discharge, and at the same time decrease markedly the mean arterial pressure. (2) Microinjection of 0.3 nmol yohimbin into CNTS had no significant influence on FRND and MAP, but could attenuate and even reverse the effects of NE on FRND and MAP. These results suggest that micro-injection of NE into CNTS may activate the alpha-adrenorecptor located in CNTS and secondarily produce a depressor effect by attenuating the activity of peripheral sympathetic nervous system.
Similar content being viewed by others
References
Ding H, Wu J H, Yang K. Cardio-vascular effects elicited by norepinephrine in the subnucleus commissurius of nucleus solitarius tractus mediated by opioid system. Acta Physiol-Sin 1987, 39 (4): 385
Nobutaka Doba. Acute fulminating neurogenic hypertension produced by brainstem lesion produced by brainstem lesions in the rat. Circ Res, 1973, 32(5): 584
Nobutaka Doba. Role of central and peripheral adrenergic mechanisms in neurogenic hypertension produced by brainsteim lesion in rat. Circ Res, 1974, 34(3): 293
Ji S M, He R R. Microinjection of adrenomedullin into rostroventrolateral medulla increases blood pressure, heart rate, and renal sympathetic nerve activity in rats. Acta Physiologica Sinica, 2002, 54 (5): 460
Zhou M, Gebhart G F. Altered descending modulation from the rostroventral medulla in the capsaicin-treated rats. Soc Neurosci Abstr, 1992, 18:685
Author information
Authors and Affiliations
Additional information
ZHANG Yi, female, bron in 1953. Technician in Charge
Rights and permissions
About this article
Cite this article
Yi, Z., Hongyan, L., Shenghong, L. et al. Mechanisms of depressor effect of norepinephrine injected into subnucleus commissuriu of nucleus solitarius tractus in rabbits. Current Medical Science 25, 263–264 (2005). https://doi.org/10.1007/BF02828137
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02828137