Summary
We describe a malignant mucinous cystic neoplasm of the pancreas with ovarian-like stroma within which an osteoclast-like giant cell rich tumor arose. This rare tumor had a unique immunohistochemical profile with the giant cells staining for vimentin, leukocyte common antigen, and the monocyte/macrophage marker CD68, whereas the mucinous epithelium stained for epithelial membrane antigen and cytokeratin. The immunohistochemical findings are consistent with two lines of differentiation, one epithelial and the other suggesting mesenchymal differentiation of the giant cell tumor with an immunophenotype similar to giant cell tumor of bone. The coexistence of these two rare tumors suggests that they are histogenetically related. The finding of a giant cell tumor arising in the ovarian stroma indicates that the stroma of mucinous tumors is not always an innocuous component of the tumor.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Lewandrowski K, Weston L, Dickersin G, Rattner D, Compton C. Giant cell tumor of the pancreas of mixed osteoclastic and pleomorphic all type: evidence for a histogenetic relationship and mesenchymal differentiation.Hum Pathol 1990; 21: 1184–1187.
Rosai J. Carcinoma of the pancreas simulating giant cell tumors of bone. Electron microscopic evidence of its acinar origin.Cancer 1968; 22: 333–344.
Mentes A, Yüce G. Osteoclast-type giant cell tumor of the pancreas associated with mucinous cystadenoma.Eur J Surg Oncol 1993; 19: 84–86
Posen JA. Giant cell tumor of the pancreas of the osteoclast type associated with a mucinous secreting cystadeno-carcinoma.Hum Pathol 1981; 12: 944–947.
Dressler LG, Bartow SA. DNA flow cytometry in solid tumors: practical aspects and clinical applications.Semin Diagnostic Pathol 1989; 6: 55–82.
Micklem K, Rigney E, Simmons D, Cordell J, Stross P, Turley H, Seed B, Mason D. A human macrophage-associated antigen (CD68) detected by six different monoclonal antibodies.Br J Heamatol 1989; 73: 6–11.
Tsujimura T, Kawana K, Taniguchi M, Tsukaguchi I. Malignant fibrous histiocytoma coexistent with a mucinous cystadenoma of the pancreas.Cancer 1992; 70: 2792–2796.
Rego J, Ruvira L, Garcia A, Freijanes S, Penaranda M, Soto J. Pancreatic mucinous cystadenocarcinoma with pseudosarcomatous mural nodules.Cancer 1991; 67: 494–498.
Prat J, Scully R. Sarcomas in ovarian mucinous tumors. A report of two cases.Cancer 1979; 44: 1327–1331.
Fisher HP, Altmannsberger M, Kracht J. Osteoclast-type giant cell tumor of the pancreas.Virch Arch [A] 1988; 412: 247–253.
Robinson L, Damjenow I, Brezind P. Multinucleated giant cell neoplasm of the pancreas.Arch Pathol Lab Med 1977; 101: 590–593.
Berent R, Shnitka K, Wiens E, Manickavel V, Jewell L. The osteoclast type giant cell tumor of the pancreas.Arch Pathol Lab Med 1987; 111: 43–48.
Goldberg RD, Michelassi F, Montag AG. Osteoclast like giant cell tumor of the pancreas. Immunophenotypic similarity to giant cell tumor of bone.Hum Pathol 1991; 22: 618–622.
Medeiros LJ, Beckstead JH, Rosenberg AE, Warnke RA, Wood GS. Giant cells and mononuclear cells of giant cell tumor of bone resemble histiocytes.Appl Immunohistochem 1993; 1: 115–122.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bergman, S., Medeiros, L.J., Radr, T. et al. Giant cell tumor of the pancreas arising in the ovarian-like stroma of a mucinous cystadenocarcinoma. Int J Pancreatol 18, 71–75 (1995). https://doi.org/10.1007/BF02825424
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02825424