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Hepatitis B, C & D viral markers in multitransfused thalassemic children: Long term complications and present management

  • Symposium: Hepatology—Part II
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References

  1. Choudhry VP, Desai N, Pati HP and Nanu A. Current management of homozygous beta thalassemia.Ind. Pediatr 1991; 28: 1221–1229.

    CAS  Google Scholar 

  2. Froesner GG, Schomerus H, Widemann KH, et al. Diagnostic significance of quantitative determination of hepatitis B surface antigen in acute and chronic hepatitis B infection.Eur J Clin Microbiol 1982; 1: 52–58.

    Article  Google Scholar 

  3. Hoofnagle JH, Shafritz DH and Popper H. Chronic type B hepatitis and the “healthy” HBsAg carrier state.Hepatology 1987; 7: 758–763.

    Article  PubMed  CAS  Google Scholar 

  4. Ou J, Laub O and Rutter W. Hepatitis B vbirus gene function. The precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen.Proc Antl Acad Sci USA 1986; 83: 1575–1582.

    Google Scholar 

  5. You JY, Howerd R, Waggoner JG and Hofnagle JH. Peroxidase anti-peroxidase detection of hepatitis B surface and core antigen in liver biopsy specimens from patients with chornic type B hepatitis.J Med Virol 1978; 2: 77–87.

    Article  Google Scholar 

  6. Hadziyannis SJ, Lieberman HM, Karvountzis GG and Shafrtiz DA. Analysis of liver disease, nuclear HBcAg, viral replication, and hepatitis B virus DNA in liver and serum of HBeAg vs anti-HBe positive carriers of hepatitis B virus.Hepatology 1983; 3: 656–662.

    PubMed  CAS  Google Scholar 

  7. Kenako S, Miller RH, di Bisceglie AM, et al. Detection of hepatitis B virus DNA in serum by polymerasc chain reaction.Gastroenterology 1990; 99: 799–804.

    Google Scholar 

  8. Perrillo RP, Schiff ER, Davis GL, et al. A randomized controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B.N Engl J Med 1990; 323: 295–301.

    Article  PubMed  CAS  Google Scholar 

  9. Scolnick EM, McLean AA, West DJ, et al. Serologic resoponses in healthy adults of a hepatitis B vaccine made by recombinant DNA.JAMA 1984; 251: 2812–2815.

    Article  PubMed  CAS  Google Scholar 

  10. Shiels MT, Taswell HF, Czaja AJ, et al. Frequency and signficance of concurrent hepatitis B surface antigen and antibody in acute and chornic haptitis B.Gastroenterology 1976; 93: 675–680.

    Google Scholar 

  11. Chau KH, Hargio MP, Decker RH, et al. Serodiagnosis of recent hepatitis B infection by Igm class anti-HBc.Hepatology 1983; 3: 142–149.

    Article  PubMed  CAS  Google Scholar 

  12. Sjogren M and Hoofnagle JH. Immunoglobulin M antibody to hepatitis B core antigen in patients with chronic type B hepatitis.Gastroenterology 1985; 89: 252–258.

    PubMed  CAS  Google Scholar 

  13. Carman WF, Jacyna MR, Hadziyannis S, et al. Mutation preventing formation of hepatitis Be antigen in patients with chronic hepatitis B infection.Lancet 1989; 335: 588–591.

    Article  Google Scholar 

  14. Choo Q-L, Luo G, Winer AJ, et al. Isolatio of aa DNA Clone dervied from a blood-borne non-A, non-B viral hepatits genome.Science 1989; 244: 359–362.

    Article  PubMed  CAS  Google Scholar 

  15. Kuo G, Choo Q-L, Alter HJ, et al. An assay for circulating antibodies to a major etiologic virus of human non-A, non B hepatitis.Science 1989; 244: 362–364.

    Article  PubMed  CAS  Google Scholar 

  16. Alter HJ, Purcell RH, Shih JW, et al. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis.N Engl J Med 1989; 321: 1494–1500.

    Article  PubMed  CAS  Google Scholar 

  17. Garons JA, Tedder RS, Briggs M, et al. Detection of hepatitis C viral sequences in blood donation by “nested” polymerase chain reaction and prediction of infectivity.Lancet 1990; 336: 1419–1422.

    Google Scholar 

  18. Hoofnagle JH and Bisceglie AMD. Serologic diagnosis of acute and chronic viral hepatitis.Seminar Liv Dis 1991; 11: 73–83.

    CAS  Google Scholar 

  19. Smedile A, Lavarini C, Vrivelli O, et al. Radioimmuno assay detection of Igm antibodies to the HDV-associated delta antigen. Clinical significance in delta infection.J Med Virol 1982; 9: 131–138.

    Article  PubMed  CAS  Google Scholar 

  20. Gulati S, Marwala RK, Dilawari JB, et al. Serologial responses to hepatitis B virus infection in multitransfused thalassemic children.Ind pediatr 1991; 29: 73–77.

    Google Scholar 

  21. Mittal MK, Vij JC, Talukdar B, Sachdev HPS and Saini L. Prevalence of hepatitis B virus markers in multitransfused thalassemic patients.2nd Pediatr 1988; 25: 161–165

    Google Scholar 

  22. Kapil D, Growth and Development, liver and cardiac dysfunction following multiple blood transfusion in patients of thalassemia. Thesis submitted to All India Institute of medical Sceinces. New Delhi 1989.

  23. Bhattacharya DK, Bhattacharjee S, De M, and Lahiri P. Prevalence of hepatitis C in transfusion dependent thalassemic and haemophilics.Ind J Med Ped 1991; 94: 430–432.

    CAS  Google Scholar 

  24. Amarapukar DN, Kumra A, Vaidya S, et al. Frequency of hepatitis B, C and D and human immunodeficiency virus infection in multitransfused thalassemics.Ind J Gastroenterology 1992; 11: 80–1.

    Google Scholar 

  25. William TN, Wonke B and Donoku SM, A Study of Hepatitis B and C prevalence and liver unction in multitransfused thalassemia and their parents.Ind Peiatr 1992; 29: 1119–24.

    Google Scholar 

  26. Jolly JG, Agnihotri SK, Choudhry N, and Gupta D, Evaluation of haemotherapy in thalassemia (20 years of India experience).J Ind Med Anoc 1992; 90: 7–9.

    CAS  Google Scholar 

  27. Chopra K and Popli V. Prevalence of hepatitis B and hepatitis C in mulitiransfused thalassemics. XXXII National conference of India Academy of Pediatrics (Abstract) 1994; 44–45.

  28. Manglani M, Kanabia S, Bhatia N, et al. Liver function tests, hepatitis-B markers and HIV in multiply transfused thalassemics XXXII Natinal conference of Indian Academy of Pediatrics (Abstract) 1994: 53–54.

  29. Choudhry UP, Charya SK, Prasanna U, et al. Hepatitis B and C viral markers amongst multitransfused thalassemic children (paper submitted for publication).

  30. Wonke B, Hoffbrand A. V., Brown D, et al. Antibody to hepatitis C virus in multiply transfused patients with thalassemia major.J clin Pathol 1990; 43: 638–640.

    Article  PubMed  CAS  Google Scholar 

  31. de Montaiembert M, Costagliola DG, Lefrere JJ, et al. Prevalence of markers for human immunodeficiency virus types I and II human Tlymphotropic virus type I, cytomegalovirus, and hepatitis B and C virus in multiply transfused thalassemia patients.Transfusion 1992; 32: 509–512.

    Article  Google Scholar 

  32. Ca copardo B, Runo R, Fatuzzo O, et al. HCV and HBV infection amoung multitransfused thalassemics from eastern sicily.Infection 1992; 20: 83–85.

    Article  CAS  Google Scholar 

  33. Dentico P, Buongiorno R, Volpe A, et al. Long term persistence of anti HBs after hepatitis B immunization in thalassemic patients.Infection 1992; 20: 276–278.

    Article  PubMed  CAS  Google Scholar 

  34. Resti M, Azzari C, Rossi ME, et al. Hepatitis virus antibodies in a long term follow up of beta thalassemic children with acute and chronic non-A non-B hepatitis.Eur J Pediatr 1992; 1151: 573–576.

    Article  Google Scholar 

  35. al-Fawaz I and Ramia S. Decline in hepatitis B infection in sickle cell anemia & beta thalassemia major.Arch Dis child 1993; 69: 594–596.

    Article  PubMed  CAS  Google Scholar 

  36. Lau YL, Chow CB, Lee AC, et al. Hepatitis C virus antibody in multiply transfused chinese with thalasemia majorBone Marrow Transplant 1993; 12: 26–28.

    PubMed  Google Scholar 

  37. Resti M, Azzasi C, Rossi ME, et al. Hepatitis C virus antibodies in a long term follow up of beta-thalassemic children with acute and chronic non-A and non-B heaptitis.Eur J Pediatr 1992; 151: 573–760.

    Article  PubMed  CAS  Google Scholar 

  38. Franks AL, Berg CJ, Kane MA, et al. Hepatitis B virus infection among children born in the United States to southeast Asian refugees.N Engl J Med. 1989; 32: 1301–1305.

    Article  Google Scholar 

  39. Hurie MB, Mast EE, Davis JP. Horizontal transmission of hepatitis B virus infection to United States-born children of Hmong refugees.Pediatrics 1992; 89: 269–273.

    PubMed  CAS  Google Scholar 

  40. Carman WF, Jacyna MR, Hadziyannis S, et al. Mutation preventing formation of hepatitis Bc antigen in patients with chronic hepatitis B infectin.Lancet 1989; 2: 588–591.

    Article  PubMed  CAS  Google Scholar 

  41. Brunetto MR, Stempler M, Borino F, et al. A new haptitis B virus strain in patients with severe anti HBe positive chronic hepatitis B.J Hepatol 1990; 10: 258–261.

    Article  PubMed  CAS  Google Scholar 

  42. Tong MJ, Sampliner RE, Govindrajan S, et al. Spontaneous reactivation of hepatitis B in chinese patients with HBsAg positive chronic active hepatitis.Hepatology 1987; 7: 713–718.

    Article  PubMed  CAS  Google Scholar 

  43. Lai ME, Mazzoleni AP, Srgiolu F, et al. Hepatitis C virus in multiple episodes of acute hepatitis in polytransfused thalassemic children.Lancet 1994; 343:388–90.

    Article  PubMed  CAS  Google Scholar 

  44. Aach RD, Lander JI, Sherman LA, et al. Transfusion transmitted viruses. Interim analysis of hepatitis among transfused and non-transfused patients. In: Vyas GN, Cohen SN. Schmied R, Eds.Viral hepatitis. Philadelphia, Franklin Institute Press, 1978; 383–396.

    Google Scholar 

  45. Dienstage JL: non-A, Non-B hepatitis I. Recognition, epidemiology, and clinical features.Gastroenterology 1983; 85: 439–462.

    Google Scholar 

  46. Dienstag JL. non-A, non-B hepatitis. II. Experimental transmission putative virus agents and markers, and prevention.Gastroenterology 1983; 85: 743–768.

    PubMed  CAS  Google Scholar 

  47. Bradley DW, Maynard JE. Etiology and natural history of post-transufion non-A, non-B hepatitis.Semin Liver Dis 1986; 6: 56–66.

    PubMed  CAS  Google Scholar 

  48. Alter HJ: Chronic sequences of non-A, non-B hepatitis. In: Seef LB, Lewis JH, eds.Current perspectives in Hepatology. New York, Plenum Publishing. 1989: 83–97.

    Google Scholar 

  49. Kiyosawa K, Akahoma Y, Nagata A, Furuta S. Hepatocellular carcinoma after non-A, non-B postransfusion hepatitis.Am J Gastroenterol 1987; 78: 777–781.

    Google Scholar 

  50. Tremolada F, Benvegun L, Casarin C, et al. Antibody to hepatitis C virus in hepatocellular carcinoma.Lancet 1990; 1: 300–301.

    Article  Google Scholar 

  51. Nishioka K: Postransfusion hepatitis C. Proceedings of the second international symposium on HCV Los Angeles. November 1990. p 36.

  52. Bruix J, Calvet X, Costa J, et al. Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis.Lancet 1989; 2: 1004–1006.

    Article  PubMed  CAS  Google Scholar 

  53. Colombe M, Choo GL, Del Ninno E. Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma.Lancet 1989; 2: 1006–1003.

    Article  Google Scholar 

  54. Tabashashi M, Yamada A, Mijamoto R,et al. Natural course of hepatitis C.Am J Gastroenterol 1993; 88: 240–243.

    Google Scholar 

  55. Seeff LB, Bushell-Bales 2, Wright E, et al. Long term mortality after transfusion associated non-A, non-B hepatitis.N Engl J Med 1992; 327: 1906–1911.

    Article  PubMed  CAS  Google Scholar 

  56. Hoofnagle JH, Hanson RG, Minuk GY, et al. Randomized, controlled trial of adenine arabinoside monophosphate for chronic type B hepatitis.Gastroenterology 1984; 86: 150–157.

    PubMed  CAS  Google Scholar 

  57. Perillo RP, Regenstein FG, Bodicky CJ, et al. Comparative efficacy of adenine arabinoside 5 monophosphate and prednisone withdrawal followed by adenine arabinoside 5′ monophosphate in the treatment of chronic active hepatitis type B.Gastroenterology 1985; 88: 780–786.

    Google Scholar 

  58. Alexander GJM, Fagan EA, Hegarty JE, et al. Controlled clinical trial of acyclovir in chronic hepatitis B virus infection.J Med Viron 1987; 21: 81–87.

    Article  CAS  Google Scholar 

  59. Perrillow RP, and Mason AL. Therapy for hepatitis B virus infection.Gastro clin N Am 1994; 23: 581–601.

    Google Scholar 

  60. Sztein MB and Goldstein AL. Thymic Hormones a clinical update.Springer Semin Immunopathol 1986; 9: 1–18.

    Article  PubMed  CAS  Google Scholar 

  61. Mutchinck MG, Appelman HD, Chung HT, et al. Thymosin treatment of chornic hepatitis B. A placebo controlled pilot trrial.Hepatology 1991; 14: 409–415.

    Google Scholar 

  62. Jain S, Thomas HC, Oxford JS, et al. Trial of rivavirin for the treatment of HBsAg positive chronic liver disease.J Antimicrob Chemiother 1978; 4: 367–373.

    Article  CAS  Google Scholar 

  63. Fried MW, Fong TL, Swain MG, et al. Hepatitis B virus (HBV) DNA suppression during long-term therapy with ribavirin (abstract).Gastroenterology 1992; 10-A808.

    Google Scholar 

  64. Peters M. Mechanisms of action of interferons.Semin Liver Dis 1989; 9: 235–239.

    PubMed  CAS  Google Scholar 

  65. perriollo RP, Schiff ER, Davis GL, et al. A Randomized controlled trial of interferon alfa-2b alone and after prednisone withdrawal, in the treatment of chronic hepatitis B.N Engl J Med 1990; 323: 295–301.

    Article  Google Scholar 

  66. di Bisceglie AM, Bergasa NV, Fong TL, et al. A randomized controlled trial of recombinant alfa interferon therapy for chronic hepatitis B (abstract)Hepatology 1991; 13: 70A

    Google Scholar 

  67. Karayiannis P, Kanatakis S, Thomas HC, Anti-HBs response in seroconverting chronic HBV carriers following alfa-interferon treatment.J Hepatol 1990; 10: 350–352.

    Article  PubMed  CAS  Google Scholar 

  68. Davis GL, Balart LA, Schift ER, et al. Treatment of chronic hepatitis C with recombinant interferon alfa; A multicenter randomized, controlled trial.N Engl J Med 1989; 321: 1501–1506.

    Article  PubMed  CAS  Google Scholar 

  69. Davis GL and Lau JYN. Hepatitis C. In: Haubrich W, Schaffner F, Berk J eds.Bockus Gastroenterology, Philadelphia: WB Sacenters, 1994.

    Google Scholar 

  70. Marcellin P, Boyer N, Giostra E, et al. Recombinant human alfa interferon in patients with chronic non-A, non-B hepatitis. A multicenter randomized controlled trial from France.Hepatology 1991; 13: 393–397.

    PubMed  CAS  Google Scholar 

  71. Shindo M, Di bisceglie AM, Cheung L, et al Decrease in serum hepatitis C virual RNA during alfa-interferon therapy for chronic hepatitis C.Ann inter Med 1991; 115: 700–704.

    CAS  Google Scholar 

  72. Tine F, Nagrin S, Crasci, A, et al. Interferon for non A non B chronic hepatitis. A metanlaysis of randomised clinical trials.J Hepatol 1991; 13: 192–199.

    Article  PubMed  CAS  Google Scholar 

  73. Tolini G, Furlan C, Glimalid, F, et al. One course versus two courses of recombinant of alfa interferon in chronic hepatitis C Arch.Viral suppl. 1992; 4: 294–298.

    Google Scholar 

  74. Davis GL, Lindsay K, Albrecht J, et al. Predictors of response to recombinant alfa interferon treatment in patients with chronic hepatits C (abstract)Hepatology 1990; 12: 905.

    Google Scholar 

  75. Di Marco U, Lo Iaconod, Capra M, et al. Alpha interferon treatment of chornic hepatitis C in beta thalassemia.Gut 1993; 34: S 142–143.

    Article  Google Scholar 

  76. Wonke B, Donohue SM, Haffbrand AV, et al. Recombinant alfa 2 B interferon (IFN) in the treatment of chronic hepatitis C disease in the thalassemia major.Bone Marrow Transplant 1993; 1: 24–25.

    Google Scholar 

  77. Clemente MG, Congia M, Lai ME, et al. Effect of iron. Overload on the response to recombinant interferon alfa treatment in transfusion dependent patients with thalassemia major and chronic hepatitis C.J Pediatr 1994; 125: 123–128.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Hematology and Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, 110029, New Delhi

    V. P. Choudhry & S. K. Acharya (Associate Professor)

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  1. V. P. Choudhry
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  2. S. K. Acharya
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Choudhry, V.P., Acharya, S.K. Hepatitis B, C & D viral markers in multitransfused thalassemic children: Long term complications and present management. Indian J Pediatr 62, 655–668 (1995). https://doi.org/10.1007/BF02825110

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