Conclusion
It appears that an ideal vaccine would be the one which closely simulates the immunologic events occurring during the course of natural infection. Natural infection through the natural portal of entry seems to induce serum as well as secretory antibody response. Live attenuated vaccine administered orally most closely resembles natural infection in eliciting a balanced immunologic response. However, parenteral immunization with inactivated vaccine may be complicated by unbalanced immune response stimulating the humoral system without any secretory antibody production. Current approaches in immunoprophylaxis of viral disease are thus directed at immune mechanisms which lead to uniform stimulation of only certain components of the immune system. Hopefully, this approach would lead to balanced immunologic responses rather than a situation of altered immunity and hypersensitivity. Further, the success which has been attained with the use of live attenuated vaccine, suggests that the development of local immunity at the primary portal of entry may eventually provide an effective means of eradication of pathogenic virus flora in any community.
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From the Department of Pediatrics, School of Medicine, State University of New York at Buffalo, and the Virology Laboratory, Children's Hospital, Buffalo, N. Y.
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Ogra, P.L. Immunoprophylaxis of viral infections in childhood. Indian J Pediatr 37, 376–394 (1970). https://doi.org/10.1007/BF02822936
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DOI: https://doi.org/10.1007/BF02822936