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Pancreatic carcinoma following gastric resection

A case-control study based on 21,660 consecutive clinical necropsies at Malmö University Hospital

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Summary

Conclusion

In this necropsy-based case-control study, there was no relationship between pancreatic carcinoma and previous gastric resection. Based on the association between lung cancer and gastric resection, it is suggested that the relationship between pancreatic carcinoma and gastric resection shown in other studies may have been confounded by smoking.

Background

This case-control study was designed to assess whether in patients dying from pancreatic carcinoma, there is a relationship to previous gastric resection for peptic ulcer disease.

Methods

By linking the autopsy data base in Malmö with the national Cause of Death Register, we identified 439 autopsied individuals who had died of pancreatic carcinoma between 1970 and 1982. The 21,660 individuals in the data base represent 64% of all deaths during that time period. For each of these individuals who died of pancreatic carcinoma, we randomly chose three controls who were matched for age at death, gender, and year of death. In order to assess the specificity of the assumed relationship, we also used as a control group the 1337 autopsied individuals who had died of lung cancer.

Results

The prevalence of previous gastric resections was 3.4% in patients dying from pancreatic carcinoma, 7.6% in patients dying from lung cancer, and 4.4% in the age-and sex-matched control group. The odds for previous gastric resection in patients dying from pancreatic carcinoma was 0.9 [95% confidence interval (CI) 0.5–1.7] in comparison with this age- and sex-matched control group. The lower odds for previous gastric resection in patients dying of pancreatic carcinoma than in patients dying of lung cancer remained in the logistic regression analysis after controlling for age at death, gender, and year of death (odds ratio [OR] 0.5; 95% CI 0.3–0.9).

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Authors and Affiliations

  1. Department of Community Medicine; Division of Epidemiology, Lund University, University Hospital MAS (UMAS), S-205 02, Malmö, Sweden

    Mats Ögren & Lars Janzon

  2. Department of Pathology, Lund University, University Hospital MAS (UMAS), S-205 02, Malmö, Sweden

    Nils H. Sternby

  3. Department of Surgery, Lund University, University Hospital MAS (UMAS), S-205 02, Malmö, Sweden

    Mats Hedberg

Authors
  1. Mats Hedberg
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  2. Mats Ögren
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  3. Lars Janzon
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  4. Nils H. Sternby
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Hedberg, M., Ögren, M., Janzon, L. et al. Pancreatic carcinoma following gastric resection. Int J Gastrointest Canc 21, 219–224 (1997). https://doi.org/10.1007/BF02821607

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  • DOI: https://doi.org/10.1007/BF02821607

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